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Table 2 Stability enrichment for the Grb2-Vav 3D dimer

From: Neutral evolution of Protein-protein interactions: a computational study using simple models

k

viable sequences

⟨n⟩ ss

Φ(Z)

1

537

14.13

1.05

2

30801

4.65

1.07

3

67291

3.50

1.08

4

109954

3.07

1.18

5

157903

3.07

1.18

6

211133

3.01

1.06

7

269022

3.00

1.07

8

331852

2.96

1.07

9

398776

2.99

1.04

10

470334

3.00

1.04

  1. Steady state enrichment factor Φ(Z) of the dimerization ability (measured by the Z-score) for the Grb2-Vav 3D dimer as a function of the functional constraint (measured by k). The number of viable sequence profile pairs and the mean mutational robustness ⟨n⟩ ss are also shown.
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BMC Structural Biology

ISSN: 1472-6807

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