Figure 7
Viperidae SVPLA 2 interface amino acid residues. Interface amino acid residues of the SVPLA2 complexes with FXa (CBc, MtxII, CbII, AtxA and CBa2). Underlined characters denote residues identified by mutagenesis to be critical for binding to FXa and inhibition of prothrombinase activity [39, 51]. Bold characters denote residues defining the IBS of hsPLA2 [13, 14]. Cyan-shadowed characters denote residues found at the interface of the selected complexes. The alignment reflects Renetseder's numbering system.