Figure 5

Comparison of the binding pocket for a phenol derivative as seen in other structures and the position for hexamer-hexamer interaction as observed in this study. In (a), the phenolic binding pockets of 1EVR (blue) and 1EV6 (purple) are superposed. One resorcinol and one meta-cresol molecule is shown to bind in the pocket created by the two flanking tyrosine residues. The side chain of the tyrosine to the right in 1EVR is missing in the pdb file. In (b) the same structures are superposed with the C222₁urea structure (orange). The side chain of the left tyrosine is flipped to accommodate the hexamer-hexamer interaction shown in (c), where a neighboring hexamer from the asymmetric unit is included (grey). The tyrosine side chain of the second hexamer occupies the same position as the phenolic compounds.