BMC Structural Biology

Table 1 Conserved properties and interactions for barrel and helix 2.

From: Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling

Position	Struct. Info.		Conserved properties(10/10)			Conserved Interactions
	In/out	2^nd				11/11	10/10	9/10
42	in	loop	pho	Gly	Small (x)
48	in	βA	pho (x)	arom (x)	bulky (x)		80	80
				Trp				168
						190	190	190 (x)
						192	192	192 (x)
49	out	βA	pho (x)		bulky (x)
52	out	βA	pho					189
								220
55	in	Ω loop			small
74	out	Ω loop	Phi (x)
80	in	βB	pho (x)					39
							48	48
								93 (x)
91	in	βC	pho (x)					115 (x)
							131	131
93								80 (x)
110	out	βD	Phi
115	in	βD	pho (x)					91 (x)
								131 (x)
							133	133 (x)
131	in	βE	pho (x)		bulky (x)		91	91
								115 (x)
							156	156
133	in	βE	pho (x)				115	115 (x)
156	in	βF	pho				131	131
158	in	βF	pho (x)				39	39
								168
								170 (x)
159								169
								171 (x)
162	out	loop	phi (x)
165	out	loop	phi (x)
166	out	loop	phi (x)
168	out	βG	Pho					39
								48
								158
							190	190
169	in	βG	pho (x)			205	205	205 (x)
								159 (x)
170								158 (x)
								190 (x)
171								159 (x)
189								52
								205 (x)
190	in	βH	pho (x)			48	48	48 (x)
							168	168
								170 (x)
191	in	βH			Small (x)
192	in	βH	phi (x)	NEG	bulky	48	48	48 (x)
205	out	H2	pho (x)			169	169	169 (x)
								189 (x)
214	out	loop	pho
220	out	βI	pho					52

Conserved positions based on the VAST alignment and related structural information: the position of the residue relative to the barrel; inside (in) or outside (out) and the corresponding secondary structure (2^nd). The conserved properties (10/10 conservation) are also presented, i.e. hydrophobic (pho), hydrophilic (phi), charged (NEG for negative charge), aromatic (arom), bulky/small, as well as the conserved interaction partner (for 11/11, 10/10 and 9/10 lipocalins). (x) indicates the properties and interactions shared by 1QFT.

Back to article page

ISSN: 1472-6807

Contact us

General enquiries: ORSupport@springernature.com