"Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms

Table 4 Amino acid composition of CHCs*

DATASET A		DATASET B
Amino acid	Hyperthermophiles vs. Mesophiles	Amino acid	Hyperthermophiles vs. Mesophiles
A	-1.045	A	-0.680
V	-0.107	V	-0.115
F	0.305	F	0.216
I	3.661	I	3.635
L	-1.609	L	-1.585
D	-0.451	D	-0.365
E	0.211	E	0.432
G	-0.058	G	-0.136
K	0.130	K	0.645
S	-0.245	S	-0.355
T	-0.398	T	-0.554
Y	0.471	Y	0.821
C	-0.850	C	-0.683
N	0.285	N	0.231
Q	-0.813	Q	-0.933
P	0.334	P	0.207
M	-0.036	M	-0.412
R	0.500	R	0.114
H	-0.167	H	-0.284
W	-0.407	W	-0.398

* Values are expressed in units of standard deviation from the mean (Z-score). R values ≥ 3.0 are considered statistically significant and are bolded.