BMC Structural Biology

Table 6 Preferred amino acid interactions in CHCs. Thermophilic versus mesophilic proteins of dataset B are compared*

From: "Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms

	ALA	VAL	PHE	ILE	LEU	ASP	GLU	GLY	LYS	SER	THR	TYR	CYS	ASN	GLN	PRO	MET	ARG	HIS	TRP	XXX
ALA	-0.81
VAL	-0.80	-0.62
PHE	0.29	-0.96	-0.09
ILE	3.27	6.36	2.80	4.21
LEU	-1.86	-2.02	0.68	4.17	-4.10
ASP	-0.76	-0.23	-0.58	1.21	-0.49	-0.23
GLU	0.13	0.58	0.51	0.79	1.37	0.11	0.89
GLY	-0.44	-0.77	-0.50	1.11	-0.26	-0.53	0.57	-0.34
LYS	-0.46	0.10	0.75	2.51	1.69	0.37	3.28	0.65	1.16
SER	-1.04	-1.38	-0.36	1.47	-0.05	-0.22	0.05	-0.63	0.78	0.06
THR	-2.05	-1.15	-0.80	0.17	-0.90	-0.12	-0.89	0.00	0.49	-0.15	0.42
TYR	0.60	1.74	0.90	3.06	-0.54	0.67	0.64	0.49	0.84	0.53	0.48	0.86
CYS	-1.56	-1.49	-0.83	-0.64	-2.55	-0.14	-0.08	-0.48	-0.26	-0.57	-0.53	-0.30	-0.12
ASN	0.48	0.31	0.15	-0.02	-0.70	-0.04	0.23	0.35	0.49	-0.11	-0.42	-0.15	0.01	0.08
GLN	-1.58	-1.09	-0.33	-0.38	-2.48	-0.88	-1.02	-0.79	-0.27	-0.73	-1.02	-0.65	-0.24	-0.19	-0.42
PRO	0.13	-0.94	0.47	0.16	-0.37	0.04	0.72	0.62	0.70	-0.22	-0.26	-0.01	-0.47	0.21	-0.75	0.09
MET	-0.86	-0.50	0.09	1.19	-0.84	-0.21	0.72	-0.53	0.35	0.05	0.09	-0.52	-0.60	0.01	-0.36	0.11	-0.05
ARG	-1.22	0.26	-0.11	1.52	-0.12	-0.44	0.75	0.02	-0.20	-0.61	-0.34	0.68	-0.12	-0.11	-0.71	0.10	0.03	0.24
HIS	-0.51	0.01	-0.34	0.12	-1.45	-0.25	-0.85	0.15	-0.95	-0.28	-0.31	0.20	-0.47	-0.03	-0.26	0.11	-0.05	-0.43	0.14
TRP	-0.01	-0.23	-0.42	0.58	0.30	0.04	0.77	-0.29	0.03	-0.05	-0.15	-0.09	-0.32	-0.28	-0.09	0.19	-0.17	0.33	-0.55	0.32
XXX	0.27	0.01	0.28	0.37	0.51	0.17	0.24	0.00	0.08	0.15	0.25	0.17	0.00	0.03	0.06	0.15	0.00	0.03	-0.07	0.09	0.10

* Values are expressed in units of standard deviation from the mean (Z-score). Values ≥ 3.0 are considered statistically significant and are bolded. Mean = 0.00; standard deviation = 0.12.

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