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Table 6 Preferred amino acid interactions in CHCs. Thermophilic versus mesophilic proteins of dataset B are compared*

From: "Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms

  ALA VAL PHE ILE LEU ASP GLU GLY LYS SER THR TYR CYS ASN GLN PRO MET ARG HIS TRP XXX
ALA -0.81                     
VAL -0.80 -0.62                    
PHE 0.29 -0.96 -0.09                   
ILE 3.27 6.36 2.80 4.21                  
LEU -1.86 -2.02 0.68 4.17 -4.10                 
ASP -0.76 -0.23 -0.58 1.21 -0.49 -0.23                
GLU 0.13 0.58 0.51 0.79 1.37 0.11 0.89               
GLY -0.44 -0.77 -0.50 1.11 -0.26 -0.53 0.57 -0.34              
LYS -0.46 0.10 0.75 2.51 1.69 0.37 3.28 0.65 1.16             
SER -1.04 -1.38 -0.36 1.47 -0.05 -0.22 0.05 -0.63 0.78 0.06            
THR -2.05 -1.15 -0.80 0.17 -0.90 -0.12 -0.89 0.00 0.49 -0.15 0.42           
TYR 0.60 1.74 0.90 3.06 -0.54 0.67 0.64 0.49 0.84 0.53 0.48 0.86          
CYS -1.56 -1.49 -0.83 -0.64 -2.55 -0.14 -0.08 -0.48 -0.26 -0.57 -0.53 -0.30 -0.12         
ASN 0.48 0.31 0.15 -0.02 -0.70 -0.04 0.23 0.35 0.49 -0.11 -0.42 -0.15 0.01 0.08        
GLN -1.58 -1.09 -0.33 -0.38 -2.48 -0.88 -1.02 -0.79 -0.27 -0.73 -1.02 -0.65 -0.24 -0.19 -0.42       
PRO 0.13 -0.94 0.47 0.16 -0.37 0.04 0.72 0.62 0.70 -0.22 -0.26 -0.01 -0.47 0.21 -0.75 0.09      
MET -0.86 -0.50 0.09 1.19 -0.84 -0.21 0.72 -0.53 0.35 0.05 0.09 -0.52 -0.60 0.01 -0.36 0.11 -0.05     
ARG -1.22 0.26 -0.11 1.52 -0.12 -0.44 0.75 0.02 -0.20 -0.61 -0.34 0.68 -0.12 -0.11 -0.71 0.10 0.03 0.24    
HIS -0.51 0.01 -0.34 0.12 -1.45 -0.25 -0.85 0.15 -0.95 -0.28 -0.31 0.20 -0.47 -0.03 -0.26 0.11 -0.05 -0.43 0.14   
TRP -0.01 -0.23 -0.42 0.58 0.30 0.04 0.77 -0.29 0.03 -0.05 -0.15 -0.09 -0.32 -0.28 -0.09 0.19 -0.17 0.33 -0.55 0.32  
XXX 0.27 0.01 0.28 0.37 0.51 0.17 0.24 0.00 0.08 0.15 0.25 0.17 0.00 0.03 0.06 0.15 0.00 0.03 -0.07 0.09 0.10
  1. * Values are expressed in units of standard deviation from the mean (Z-score). Values ≥ 3.0 are considered statistically significant and are bolded. Mean = 0.00; standard deviation = 0.12.