Figure 2

Overlay of the solution structures of free and rapamycin-bound Mip^77–213. The average structures are shown in cartoon representation for free Mip^77–213 in red and for Mip^77–213 in the complex in blue. Rapamycin is shown in black. The bulge interrupting strand β₄ (residues T-144 to P-150) and the hairpin loop (residues V-179 to T-199) are highlighted.