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Figure 4 | BMC Structural Biology

Figure 4

From: Exploring allosteric coupling in the α-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches

Figure 4

Changes in local folding free energy upon "nucleotide exchange" on Gαi. Changes in free energies upon nucleotide exchange in Gαi are calculated from data given in figure 3 and mapped onto the structure of Gαi1-GTPγS (PDB ID: 1GIA). Changes are shown on the color-coded trace-tube representation of the molecule (blue: no change – red: maximum change ~6 kcal/mol). Trace-tube radius changes proportionally to the magnitude of free energy change to help visual perception. RasTop program v2.0.3 (Philippe Valadon, 2003) is used for 3D visualization.

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BMC Structural Biology

ISSN: 1472-6807

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