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Table 1 List of length-rigid and length-deviant domain superfamilies. This list is shown only for helix-rich class. Please look into Additional Tables 1 and 2 for full list. *Highly populated domain superfamilies (> 10 numbers).

From: CUSP: an algorithm to distinguish structurally conserved and unconserved regions in protein domain alignments and its application in the study of large length variations

a) List of 'Length-rigid superfamilies' (> 4 members).
S.No Class No_members Average domain size Sequence Identity Description
     (%)  
1 α 8 417 21 Cytochrome P450
2 α 6 323 14 Terpenoid synthases
3 α 8 250 25 Nuclear receptor ligand-binding domain
4 α 5 204 23 DNA-glycosylase
5 α 5 114 26 Calponin-homology domain, CH-domain
b) List of 'Length-deviant superfamilies' (> 4 members).
*6 α 22 101 24 Cytochrome c
*7 α 32 64 26 Homeodomain-like
* 8 α 48 88 21 Winged helix" DNA-binding domain
9 α 6 92 32 C-terminal effector domain of bipartite response regulator
10 α 5 90 27 Putative DNA-binding domain
*11 α 12 88 29 Histone-fold
*12 α 12 259 17 Ferritin-like
*13 α 22 142 18 4-helical cytokines
*14 α 35 125 23 EF-hand
15 α 5 75 33 Met repressor-like
16 α 6 76 37 IHF-like DNA-binding proteins
17 α 6 191 22 6-phosphogluconate dehydrogenase C-terminal domain-like
18 α 6 308 18 Terpenoid cylases/Protein prenyltransferases
19 α 9 369 17 ARM repeat
20 α 9 202 21 TPR-like