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Table 1 List of length-rigid and length-deviant domain superfamilies. This list is shown only for helix-rich class. Please look into Additional Tables 1 and 2 for full list. *Highly populated domain superfamilies (> 10 numbers).

From: CUSP: an algorithm to distinguish structurally conserved and unconserved regions in protein domain alignments and its application in the study of large length variations

a) List of 'Length-rigid superfamilies' (> 4 members).

S.No

Class

No_members

Average domain size

Sequence Identity

Description

    

(%)

 

1

α

8

417

21

Cytochrome P450

2

α

6

323

14

Terpenoid synthases

3

α

8

250

25

Nuclear receptor ligand-binding domain

4

α

5

204

23

DNA-glycosylase

5

α

5

114

26

Calponin-homology domain, CH-domain

b) List of 'Length-deviant superfamilies' (> 4 members).

*6

α

22

101

24

Cytochrome c

*7

α

32

64

26

Homeodomain-like

* 8

α

48

88

21

Winged helix" DNA-binding domain

9

α

6

92

32

C-terminal effector domain of bipartite response regulator

10

α

5

90

27

Putative DNA-binding domain

*11

α

12

88

29

Histone-fold

*12

α

12

259

17

Ferritin-like

*13

α

22

142

18

4-helical cytokines

*14

α

35

125

23

EF-hand

15

α

5

75

33

Met repressor-like

16

α

6

76

37

IHF-like DNA-binding proteins

17

α

6

191

22

6-phosphogluconate dehydrogenase C-terminal domain-like

18

α

6

308

18

Terpenoid cylases/Protein prenyltransferases

19

α

9

369

17

ARM repeat

20

α

9

202

21

TPR-like