Figure 5From: Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinaseAMP binding site. A) Stereo view of the binding site symmetry in the C. albicans TPK (green) superposed on the mouse TPK (red). Hypothetical AMP is represented with brown lines. B) Stereo view of the 2 alternative conformations of Q138A (gatekeeper) in grey with TPNP (green), Mg2+ (white) and AMP (brown lines) in the potential secondary binding site.Back to article page