Ligand-induced conformational changes in a thermophilic ribose-binding protein

Cuneo, Matthew J; Beese, Lorena S; Hellinga, Homme W

doi:10.1186/1472-6807-8-50

BMC Structural Biology

Table 1 PBPs that have structures of both ligand-bound and ligand-free forms.

From: Ligand-induced conformational changes in a thermophilic ribose-binding protein

		PDB Entry
	Protein	Apo	Complex	Reference	Hinge Bending[25]
Group I	Escherichia coli leucine-binding protein	1USG	1USI	Magnusson 2004[13]	14°
	Escherichia coli lactose repressor core	1TLF	1LBI	Friedman 1995[42]; Lewis 1996[43]	15°
	Salmonella typhimurium autoinducer precursor-binding protein	1TM2	1TJY	Miller 2004[28]	21°
	Neisseria gonorrhoeae ferric-binding protein	1R1N	1D9Y	Zhu 2003[44]; McCree Unpublished	24°
	Thermotoga maritima ribose-binding protein	2FN9	2FN8	This Work	28° *
	Escherichia coli allose-binding protein	1GUD	1RPJ	Chaudhuri 1999[45]; Magnusson 2002[7]	31° *
	Escherichia coli glucose-binding protein	2FW0	2FVY	Borrok 2007[46]	31°
	Thermotoga maritima glucose/xylose-binding protein	3C6Q	2H3H	Cuneo unpublished	38°
	Escherichia coli ribose-binding protein	1URP	2DRI	Bjorkman 1998[8]; Bjorkman 1994[24]	43° *
Group II	Rhodobacter sphaeroides α-keto acid-binding protein	2HZK	2HZL	Gonin 2007[47]	15°
	Escherichia coli nickel-binding protein	1UIU	1UIV	Heddle 2003[48]	17°
	Homo sapiens glutamate receptor	1SYH	1N0T	Frandsen 2005[49]; Hogner 2003[50]	18°
	Haemophilus influenzae ferric-binding protein	1D9V	1MRP	Bruns 2001[51]; Bruns 1997[52]	20°
	Haemophilus influenzae sialic acid-binding protein	2CEY	2CEX	Muller 2006[53]	25°
	Salmonella typhimurium oligopeptide-binding protein	1RKM	1RKM	Sleigh 1997[54]	26°
	Escherichia coli phosphate-binding protein	1OIB	1QUK	Yao 1996[55]	26°
	Mannheimia haemolytica ferric iron-Binding Protein	1SI1	1SI0	Shouldice 2004[56]	27°
	Vibrio harveyi autoinducer-binding protein	1ZHH	1JX6	Neiditch 2005[57]; Chen 2002[58]	27°
	Escherichia coli maltose-binding protein	1OMP	1ANF	Sharff 1992[14]; Quiocho 1997[59]	36°
	Sphingomonas sp. alginate-binding protein	1Y3Q	1Y3N	Momma 2005[60]	39°
	Yersinia enterocolitica hexuronate-binding protein	2UVG	2UVH	Abbot 2007[61]	44°
	Salmonella typhimurium lysine/arginine/ornithine-binding protein	2LAO	1LST	Oh 1993[62]	52°
	Escherichia coli dipeptide-binding protein	1DPE	1DPP	Nickitenko 1995[63]; Dunten 1995[64]	54°
	Thermotoga maritima maltotriose-binding protein	2GHB	2GHA	Cuneo unpublished	54°
	Escherichia coli glutamine-binding protein	1GGG	1WDN	Hsiao 1996[65]; Sun 1998[66]	56°

PBPs which have been found to adopt multiple open forms (>5° difference) are indicated with an asterisk.

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ISSN: 1472-6807

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