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Table 1 Summary of crystallographic data and model refinement

From: Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

Diffraction Data:     
Crystal Form BAU   APO  
Source SSRL 7-1   SSRL 9-1  
λ 1.00 Å   1.00 Å  
Space Group P212121   F4132  
Cell constants a = 66.20 Å   a = 253.78 Å  
  b = 74.44 Å   b = 253.78 Å  
  c = 262.71 Å   c = 253.78 Å  
Mosaicity 0.40°   0.41°  
Resolution 50-1.90 Å (1.97-1.90 Å) 50-2.3 Å (2.38-2.30 Å)
Rmerge 11.9% (44.1%) 7.2% (38.4%)
I/σ 16.1 (2.0) 30.7 (5.7)
Completeness 99.8% (100.0%) 99.9% (99.7%)
Model Refinement:     
Number of reflections 97,957   30,108  
Number of monomers/A.U. 4   1  
Atoms/A.U. 9466   2396  
   Protein 9030   2268  
   Ligand 100   6  
   Water 336   122  
Rcryst 20.5%   20.4%  
Rfree 25.1%   22.1%  
Rmsd bond lengths 0.018 Å   0.020 Å  
Rmsd bond angles 1.72°   1.68°  
Ramachandran statistics     
Most favored regions 91.5%   91.9%  
Additional allowed regions 8.5%   8.1%