BMC Structural Biology

Table 1 Summary of crystallographic data and model refinement

From: Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

Diffraction Data:
Crystal Form	BAU		APO
Source	SSRL 7-1		SSRL 9-1
λ	1.00 Å		1.00 Å
Space Group	P2₁2₁2₁		F4₁32
Cell constants	a = 66.20 Å		a = 253.78 Å
	b = 74.44 Å		b = 253.78 Å
	c = 262.71 Å		c = 253.78 Å
Mosaicity	0.40°		0.41°
Resolution	50-1.90 Å	(1.97-1.90 Å)	50-2.3 Å	(2.38-2.30 Å)
Rmerge	11.9%	(44.1%)	7.2%	(38.4%)
I/σ	16.1	(2.0)	30.7	(5.7)
Completeness	99.8%	(100.0%)	99.9%	(99.7%)
Model Refinement:
Number of reflections	97,957		30,108
Number of monomers/A.U.	4		1
Atoms/A.U.	9466		2396
Protein	9030		2268
Ligand	100		6
Water	336		122
Rcryst	20.5%		20.4%
Rfree	25.1%		22.1%
Rmsd bond lengths	0.018 Å		0.020 Å
Rmsd bond angles	1.72°		1.68°
Ramachandran statistics
Most favored regions	91.5%		91.9%
Additional allowed regions	8.5%		8.1%

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ISSN: 1472-6807

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