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Figure 4 | BMC Structural Biology

Figure 4

From: Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control

Figure 4

Overview of H5 HA trimer (PDB: 2ibx) and details of the VIN1 region. (a) Surface of HA trimer; each monomer has a different color. Carbohydrates are orange. The location of receptor binding domain (orange) and VIN1 region (yellow) are highlighted only for one monomer. (b) Ribbon representation of VIN1 region (yellow). Sulphur atoms involved in stabilization of the VIN1 region are shown as red spheres. Figures were generated by PyMol. (c) Secondary structure and amino acid composition of H5 HIN1 region. The consensus sequence of the VIN1 region is shown together with mutations found in 595 H5 HA sequences using BioEdit. Cystein residues are shown in red. (d) IS of the VIN1 region. Domains of H1N1, H3N2, H5N1, H7N1 and Spanish flu identified by consensus IS (Table 2) and their position in the 3D structure of HA1 and the IS of the peptide sequence. (e) A/New York/383/2004 (H3N2); (f) A/equine/Prague/56 (H7N7); (g) A/Egypt/0636-NAMRU3/2007(H5N1); (h) A/New Caledonia/20/99 (H1N1); (i) A/South Carolina/1/18 (H1N1).

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BMC Structural Biology

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