Figure 3
From: Molecular models of human P-glycoprotein in two different catalytic states
NBD closed dimmer. Ribbon representation (top view from the membrane) of the NBD closed dimer of one of the nucleotide-bound models in presence of two ATP molecules depicted as sticks. The N-terminal NBD (light blue) and the C-terminal NBD (light pink) are associated in a head to tail fashion. Each ATP binding pocket is formed by the A-loop (yellow), the Walker A motif (dark blue), the Walker B motif (black) and the Gln of the Q-loop depicted in orange from one NBD and is closed by the Signature motif colored in red from the other NBD.