Figure 1

Domain architecture of human Jagged-1. MNNL, N-terminal domain of Notch ligands; DSL, Delta/Serrate/Lag-2 domain; EGF domains (green) are numbered progressively; potential calcium binding EGF domains are in lighter green; VWC, von Willebrand factor type C domain; the transmembrane segment is shown as a blue bar; the receptor binding region is marked in red. Amino acid number of exon boundaries are shown on top. The amino acid sequence of J1ex6 and the disulfide bond connectivities are also shown.