Figure 4

Trace residues for partition P08 mapped onto the Dishevelled DIX domain comparative model. (A) The DIX domain is shown as grey ribbon representation and trace residues are shown as coloured balls: annotation as in Figure 3. (B) The DIX domain shown as a ball model in grey, with residues whose substitution are known to affect function coloured: residues involved in DIX dimerization and lipid-binding are coloured orange, the residue involved in actin binding is pale brown and additionally identified residues are coloured olive (see Table 2). (C) The Dishevelled DIX domain rotated 90° relative to structures in A.