Table 2 Trace residues of the human Dishevelled DIX domain

CB ^b

SB ^b

CE ^b

SE ^b

Mutant

Characterization (genetic and/or biochemical)

Reference

X

X

X

X

X

X

X

F40S (UAS-dsh^8-65) ^c

Loss-of-function

[29]

X

X

DSH2 K58A ^d

Unable to bind actin

[28]

X

X

X

X

X

X

V66A (UAS-dsh^8-19) ^{c, e}

Loss-of-function

[29]

X

DSH2 K68A ^e

Unable to homo-dimerize;

cannot interact with lipids

[11, 28]

X

DSH2 E69A^e

Unable to homo-dimerize;

cannot interact with lipids

[11, 28]

X

X

X

X

X

X

N80I (UAS-dsh^8-80) ^c

Loss-of-function

[29]

X

X

X

X

X