Figure 7

Representation of Multiple sequence alignment (using ClustalW) within class IV. The "persistent hub" and the four connecting residues are highlighted in the figure with coloured lines; the green arrow indicates the "persistent hub" and the red arrows indicate the connecting residues and are numbered arbitrarily from 1 to 4. Residue 2 and 3 are completely conserved within the class whereas residue 4 is partially conserved. However the "persistent hub" and the residue 1 are completely conserved within class IV excluding m1psy. The region marked in the orange box indicates the residues present in the mini-triad for class IV; the mini-triad sequence being absent from m1the.