A PDB-wide, evolution-based assessment of protein-protein interfaces

BMC Structural Biology

Table 3 EPPIC performance based on UniProt 2014_05

DataSet	N(>10 homo.)	Method	Sensitivity	Specificity	Accuracy	MCC
DC		Geometry	0.8025	0.7284	0.7654	0.5323
Bio	81(73)	Core Rim	0.8514	0.6462	0.7554	0.5111
Xtal	81(73)	Core Surface	0.8649	0.7059	0.7887	0.5800
		Final	0.9012	0.7160	0.8086	0.6281
Ponstingl		Geometry	0.8721	0.9231	0.8913	0.7789
Bio	86(75)	Core Rim	0.8784	0.7143	0.8333	0.5863
Xtal	52(46)	Core Surface	0.8472	0.8571	0.8500	0.6631
		Final	0.9070	0.9038	0.9058	0.8025
Many		Geometry	0.7549	0.9451	0.8513	0.7143
Bio	2831(2508)	Core Rim	0.8206	0.6580	0.7582	0.4839
Xtal	2913(2368)	Core Surface	0.8900	0.8236	0.8641	0.7142
		Final	0.8531	0.9046	0.8792	0.7590

ISSN: 1472-6807