Representative snapshots of the superposition of the trajectories of protein models with the P. abyssi Nip7 crystal structure. (A) NIP7-ABY at 300K and 100 MPa; (B) NIP7-ABY at 373K and 100 MPa; (C) NIP7-FUR at 300K and 100 MPa; (D) NIP7-FUR at 373K and 100 MPa. The Nip7 P. abyssi crystal structure is in color tube; beta strands, blue; alpha-helices, red; turns, green. Models obtained by the MD simulations are indicated by grey lines. Ovals encircle: (1) the β3-β4 loop (residues 29-41), (2) the α2-α3 segment (residues 44-61); (3) the β5-β6 loop (residues 62-79); (4) the β9-β10 loop (residues 120-125); (5) the C-terminal domain (residues 153-155).