Figure 1

A schematic model of the Dr β-clamp dimer crystal structure. In the left panel the secondary structure elements are labelled in chain A, and the molecular surface is shown. Each monomer has three domains (A, B and C) with identical topology, here coloured grey, green and pink, respectively. The right panel shows stick models of the positively charged residues on the ring interior (green), and the residues of the hydrophobic pocket located between domains B and C (pink).