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Table 3 Amino-acid residues of human progesterone receptor that were common among co-complex natural ligand, norethindrone (NET), and di-(2-ethylhexyl)phthalate (DEHP) and its five major metabolites, mono-(2-ethylhexyl)phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxyhexyl)phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl)phthalate (5-cx-MEPP), and mono-[2-(carboxymethyl)hexyl]phthalate (2-cx-MMHP)

From: Endocrine disruption: In silico perspectives of interactions of di-(2-ethylhexyl)phthalate and its five major metabolites with progesterone receptor

S. no Interacting residue S. no Interacting residue
1 Leu-715a 12 Phe-778
2 Leu-718 13 Leu-797
3 Asn-719 14 Met-801
4 Leu-721 15 Leu-887
5 Gly-722b 16 Tyr-890
6 Gln-725 17 Cys-891
7 Met-756 18 Thr-894a
8 Met-759 19 Met-909
9 Val-760   
10 Leu-763   
11 Arg-766   
  1. Amino-acid residues indicated by superscript a were not shared by MEHP and the residue indicated by superscript b was not shared by 5-OH-MEHP