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Fig. 4 | BMC Structural Biology

Fig. 4

From: Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

Fig. 4

Solvent-accessible surface area (SASA) of the three MTAP proteins and potential binding sites. a The Electrostatic Potential (EP) projected on proteins SASA is presented in red-white-blue color gradient for negatively, neutral and positively charged regions, respectively. The range of its variation is also presented. b Four binding sites (BSs) were identified by SOM-BSfinder on the SASA of the three MTAPs, each having a different surface color (pink, cyan, or green). They were ranked and colored according to descending cluster size from blue (highest neuron density associated with low U-values) to green, yellow and red (lowest neuron density associated with high U-values). The panels represent: (1) HuMTAP, (2) LiMTAP and (3) TbMTAP

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