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Fig. 5 | BMC Structural Biology

Fig. 5

From: Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

Fig. 5

Residues involved in MTA and HETA binding into the AS of the three MTAPs. MTA and HETA were docked into the ASs of the 3 proteins and the best docking poses of each ligand on each protein are shown along with residues within 4Ǻ distance. The Figures were generated when all three proteins were aligned, and from the same view angle. Panel (a) shows residues involved in MTA binding. Panel (b) shows residues involved in HETA binding. The panels show superposition of residues in presence of the docked ligand: (1) from LiMTAP (cyan) and TbMTAP (green); (2) from LiMTAP (cyan) and huMTAP (magenta); (3) from TbMTAP (green) and huMTAP (magenta)

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BMC Structural Biology

ISSN: 1472-6807

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