Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling

Table 2 SOD1 mutant clustering by H_m rows

No	SOD1 mutants	S_H	ST, years
1	A4V, V7E, G37R, G41S, G41D, H43R, H46R, H48Q, D76V, L84F, L84 V, G85R, N86 K, A89V, D90A, G93R, E100G, D101N, S105 L, L106 V, I112T, D124V, D125H, G127R, N139H, L144S	0.00	5.6 ± 5.4
2	G10 V, L38 V, I112M, V148I	0.31 ± 0.06	2.0 ± 0.7
3	F20C, G114A	0.94 ± 0.06	2.3 ± 0.4
4	C6G, L8Q, G12R	0.67 ± 0.06	2.4 ± 2.2

ST denotes mean survival time of patients with mutations from the corresponding cluster. Standard deviations were given after “±” symbol

ISSN: 1472-6807