Protein | Sildenafil (Viagra) | Tadalafil (Cialis) | Vardenafil (Levitra) |
---|---|---|---|
M.tb dimer model (Rv1554) | Phe22, Arg25, Glu26, Trp83, Ser86, Ala87, Arg89, Ala90 | Phe22, Arg25, Glu26, Trp83, Ser86, Ala87, Arg89, Ala90 | Ser18, Arg21, Phe22, Arg25, Glu26, Trp83, Ser86, Arg89 |
(Rv1555) QP site | Trp20, Phe23, Ser24, His84, Arg85, Phe88 | Trp20, Phe23, Ser24, His84, Arg85, Phe88 | Trp20, Phe23, His84, Arg85, Phe88 |
M.tb monomer model (Rv1555) QD site | Val33, Val36, Leu37, Leu40, Phe41, Leu58, Val70, Val71, Leu74, Met121 | Val36, Leu37, Leu38, Leu40, Phe41, Leu58, Val62, Val71, Leu74, Val75, Met121 | Val33, Val36, Leu37, Leu38, Leu40, Phe41, Leu58, Val70, Val71, Leu74, Val75, Met121 |
Crystal structures of human PDE5 -drug complexes | (1UDT– VIA) Tyr612,His613,Asn661, Tyr664,Ile768,Ala779, Val782,Ala783,Leu804, Met816,Gln817, Gly819, Phe820 | (1UDU– CIA) Tyr612,Ser663,Val782,Ala783, Phe786,Phe787, Leu804,Ile813, Met816, Gln817, Phe820 | (1UHO– VDN) Tyr612,His613,Tyr664, Ala779, Ala783,Phe786, Leu804, Met816, Gln817, Gly819, Phe820 |