Table 2 Somatic mutation and interacting residues in antibodies of VH5–51 and VH1–84 lineages
From: Deciphering evolution of immune recognition in antibodies
Germline lineage | PDB ID | VH mutation | Interacting residues on H-chain |
|---|---|---|---|
V H 5–51 | 4NRX | Q1, V24, A30, E32, K58, I68, N76, I89 | S31, W33, D54, D56, Y100C, R100F, T100G |
4HWB | V51, Y58 | S32, D56, S57, R60, N102, W34 | |
V H 1–84 | 2OK0 | V2, E5, E6, M33, L36, R37, K39, V51, I56, D65, A71, I77, V78, H81, D85, N87,T92 | N35, G98 |
1YJD | V2, T16, R19, E23, S31, H35, C50, N55,V56, N59, D65, I71, R85, M86, T97 | S31,Y101, G102, D104 | |
3BT2 | V2, K3, V11, S28,N31, F32, H35, F52, H52A, D55, E58, D65, A70, | Y33, W50, D55, N56, T57, E58 |