Crystallography

This section incorporates all aspects of the structural analysis of biological macromolecules using techniques in crystallography including but not limited to: studies incorporating substantial analysis by X-ray crystallography, X-ray diffraction, crystallization and/or protein expression and assays.

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  1. Database

    REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding

    More than 7000 papers related to “protein refolding” have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for...

    Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura and Kei Yura

    BMC Structural Biology 2017 17:4

    Published on: 24 April 2017

  2. Methodology article

    Controlled dehydration improves the diffraction quality of two RNA crystals

    Post-crystallization dehydration methods, applying either vapor diffusion or humidity control devices, have been widely used to improve the diffraction quality of protein crystals. Despite the fact that RNA cr...

    HaJeung Park, Tuan Tran, Jun Hyuck Lee, Hyun Park and Matthew D. Disney

    BMC Structural Biology 2016 16:19

    Published on: 3 November 2016

  3. Research article

    Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements

    Diversity-generating retroelements (DGRs) provide organisms with a unique means for adaptation to a dynamic environment through massive protein sequence variation. The potential scope of this variation exceeds...

    Sumit Handa, Blair G. Paul, Jeffery F. Miller, David L. Valentine and Partho Ghosh

    BMC Structural Biology 2016 16:13

    Published on: 31 August 2016

  4. Research article

    Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

    The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of the pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis,...

    Douglas J. Marcotte, YuTing Liu, Kevin Little, John H. Jones, Noel A. Powell, Craig P. Wildes, Laura F. Silvian and Jayanth V. Chodaparambil

    BMC Structural Biology 2016 16:7

    Published on: 1 June 2016

  5. Research article

    Crystal structure of human S100A8 in complex with zinc and calcium

    S100 proteins are a large family of calcium binding proteins present only in vertebrates. They function intra- and extracellularly both as regulators of homeostatic processes and as potent effectors during inf...

    Haili Lin, Gregers Rom Andersen and Laure Yatime

    BMC Structural Biology 2016 16:8

    Published on: 1 June 2016

  6. Research article

    Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system

    The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through t...

    Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg and Konstantin V. Korotkov

    BMC Structural Biology 2016 16:5

    Published on: 27 February 2016

  7. Research Article

    Crystal structure and functional implications of the tandem-type universal stress protein UspE from Escherichia coli

    The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative ...

    Yongbin Xu, Jianyun Guo, Xiaoling Jin, Jin-Sik Kim, Ying Ji, Shengdi Fan, Nam-Chul Ha and Chun-Shan Quan

    BMC Structural Biology 2016 16:3

    Published on: 11 February 2016

  8. Research article

    A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    BMC Structural Biology 2016 16:1

    Published on: 28 January 2016

  9. Research article

    The crystal structure of the Hazara virus nucleocapsid protein

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    BMC Structural Biology 2015 15:24

    Published on: 29 December 2015

  10. Research article

    The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins

    The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Dros...

    Sarin Chimnaronk, Jatuporn Sitthiroongruang, Kanokporn Srisucharitpanit, Monrudee Srisaisup, Albert J. Ketterman and Panadda Boonserm

    BMC Structural Biology 2015 15:17

    Published on: 16 September 2015

  11. Research article

    An intact helical domain is required for Gα14 to stimulate phospholipase Cβ

    Stimulation of phospholipase Cβ (PLCβ) by the activated α-subunit of Gq (Gαq) constitutes a major signaling pathway for cellular regulation, and structural studies have recently revealed the molecular interaction...

    Dawna HT Kwan, Ka M. Wong, Anthony SL Chan, Lisa Y. Yung and Yung H. Wong

    BMC Structural Biology 2015 15:18

    Published on: 16 September 2015

  12. Research article

    Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor

    Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface. Upstream of the catalytic domain of NanA is a domain that conforms to the s...

    Lei Yang, Helen Connaris, Jane A. Potter and Garry L. Taylor

    BMC Structural Biology 2015 15:15

    Published on: 20 August 2015

    The Erratum to this article has been published in BMC Structural Biology 2015 15:19

  13. Research article

    Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

    Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moie...

    Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh and Sylvie Garneau-Tsodikova

    BMC Structural Biology 2015 15:13

    Published on: 15 July 2015

  14. Research article

    Structure of the stationary phase survival protein YuiC from B.subtilis

    Stationary phase survival proteins (Sps) were found in Firmicutes as having analogous domain compositions, and in some cases genome context, as the resuscitation promoting factors of Actinobacteria, but with a...

    Doris H.X. Quay, Ambrose R. Cole, Adam Cryar, Konstantinos Thalassinos, Mark A. Williams, Sanjib Bhakta and Nicholas H. Keep

    BMC Structural Biology 2015 15:12

    Published on: 11 July 2015

  15. Research article

    Structural insights into Escherichia coli polymyxin B resistance protein D with X-ray crystallography and small-angle X-ray scattering

    Polymyxin B resistance protein D (PmrD) plays a key role in the polymyxin B-resistance pathway, as it is the signaling protein that can act as a specific connecter between PmrA/PmrB and PhoP/PhoQ. We conducted...

    Hunho Jo, Eui Young Jeong, Jinseong Jeon and Changill Ban

    BMC Structural Biology 2014 14:24

    Published on: 5 December 2014

  16. Research article

    High-resolution crystal structure of spin labelled (T21R1) azurin from Pseudomonas aeruginosa: a challenging structural benchmark for in silico spin labelling algorithms

    EPR-based distance measurements between spin labels in proteins have become a valuable tool in structural biology. The direct translation of the experimental distances into structural information is however of...

    Nicole Florin, Olav Schiemann and Gregor Hagelueken

    BMC Structural Biology 2014 14:16

    Published on: 29 May 2014

  17. Research article

    High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster

    The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reacti...

    Andrew M Ellisdon, Qingwei Zhang, Michelle A Henstridge, Travis K Johnson, Coral G Warr, Ruby HP Law and James C Whisstock

    BMC Structural Biology 2014 14:14

    Published on: 24 April 2014

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