Figure 7

Clust5-Sub70 - potential TYR autophosphorylation site. This cluster contains 12 microenvironments, eight of which belong to tyrosine kinases. In the eight kinase microenvironments, the CYS is on a loop next to a helix containing a TYR residue; the environment as a whole is surface-exposed and contains additional sulfur-containing residues. From left to right, we show 1K9A:A [Swiss-Prot:P32577], in which TYR416 is annotated as a putative autophosphorylation site (by similarity), 1LUF:A [Swiss-Prot:Q62838], in which TYR831 is not annotated as a potential phosphorylation site, and 1Z45:A [Swiss-Prot:P04397], a yeast aldose 1-epimerase, which is not a TYR kinase. There is, however, a surface-exposed TYR in a loop environment with an additional sulfur-containing residue.