Figure 3
![Figure 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1472-6807-10-7/MediaObjects/12900_2009_Article_303_Fig3_HTML.jpg)
The solution structure of activated fVIII derived from the MD snapshot that corresponds to 80 ns of MD simulation trajectory. The conformational reorganization of the A1-A2 acidic linker peptide (orange color), upon the cleavage of the Arg372-Ser373 bond, may be seen from the MD simulations. The exposed fIXa binding loop in the A2-domain is highlighted (magenta color).