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Figure 3 | BMC Structural Biology

Figure 3

From: Structural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics study

Figure 3

The solution structure of activated fVIII derived from the MD snapshot that corresponds to 80 ns of MD simulation trajectory. The conformational reorganization of the A1-A2 acidic linker peptide (orange color), upon the cleavage of the Arg372-Ser373 bond, may be seen from the MD simulations. The exposed fIXa binding loop in the A2-domain is highlighted (magenta color).

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