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Table 1 Interdomain hydrogen bonding interactions and corresponding distances (in Å) among A1 (1-330), A2 (381-740) and A3(1669-2019) domains of the zymogenic and activated forms of fVIII.

From: Structural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics study

fVIII zymogen Activated fVIII
A1:A2 interactions
R240 (NH1) L491 (O) 3.1 R240 (NH1) L491 (O) 2.8
T275 (OG1) D519 (OD1) 2.9 T275 (OG1) T481 (OG1) 2.9
R282 (NH1) D525 (OD1) 3.2 R282 (NH1) D525(OD1) 2.7
R282 (NH1) D525 (OD2) 2.6 R282 (NH1) D525 (OD2) 3.1
R282 (NH2) D525 (OD1) 2.8 R282 (NH2) D525 (OD2) 2.9
R484 (NH1) E272 (OE2) 2.7 S285 (OG) F673 (O) 2.6
R484 (NH2) E272 (OE2) 3.2 D482 (N) H274 (ND1) 3.0
R484 (NH2) Q305 (O) 2.9 V483 (N) G273 (O) 2.8
R490 (NH1) E341 (OE1) 2.8 R484 (NH1) E272 (O) 2.9
R490 (NH1) E341 (OE2) 3.3 R484 (NH1) E272 (OE1) 2.8
R490 (NH2) E341 (OE2) 2.9 R489 (NE) E272 (OE2) 2.9
K493 (N) F38 (O) 2.9 R489 (NH2) E272 (OE2) 2.8
K493 (NZ) D318 (OD1) 2.8 K493 (N) F38 (O) 3.1
K493 (NZ) E321 (OE1) 2.7 K493 (NZ) D318 (OD1) 3.5
K493 (NZ) E321 (OE2) 3.3 K493 (NZ) D318 (OD2) 2.9
K512 (NZ) E354 (OE1) 2.8 K493 (NZ) E321 (OE2) 2.8
Q645 (N) S314 (OG) 3.3 S674 (OG) E287 (OE2) 2.7
Q645 (NE2) S313 (O) 3.5    
S674 (OG) E287 (OE1) 2.6    
A1:A3 interactions
R226 (NH1) D1909 (OD2) 3.0 R220 (NH1) E1914 (OE2) 2.8
R226 (NH2) D1909 (OD1) 2.9 R220 (NH2) E1914 (OE1) 2.8
R226 (NH2) D1909 (OD2) 2.9 R220 (NH2) E1914 (OE2) 3.3
R1719 (NH1) D221 (OD2) 2.9 R226 (NH1) D1909 (OD1) 2.9
R1719 (NH2) D221 (OD1) 2.8 R226 (NH1) D1909 (OD2) 3.2
R1997 (NH1) E113 (O) 2.9 R226 (NH2) D1909 (OD2) 2.7
R1997 (NH2) E113 (O) 2.9 T263 (OG1) E2004 (OE2) 2.7
K1972 (NZ) D150 (OD1) 2.9 R1719 (NH1) D221 (OD1) 3.1
K1972 (NZ) D150 (OD2) 2.9 R1719 (NH1) D221 (OD2) 2.7
N1977 (ND2) S289 (OG) 2.9 R1719 (NH2) D221 (OD1) 2.7
N1977 (ND2) P290 (O) 2.8 R1997 (NH1) E113 (O) 3.2
K1992 (NZ ) Y105 (O) 2.9 R1997 (NH2) E113 (O) 2.8
    N1977 (ND2) P290 (O)  
    K1992 (NZ) Y105 (O) 2.8
A2:A3 interactions
Y664 (N) K1967 (O) 3.0 N414 (ND2) Q1906 (OE1) 2.9
T669 (OG1) P1980 (O) 3.1 Y664 (N) K1967 (O) 2.9
S695 (OG) D1842 (OD1) 2.9 S695 (OG) D1842 (OD1) 2.8
Y729 (N) E1794 (OE1) 2.8 S695 (OG) D1842 (OD2) 3.5
Y729 (OH) R1797 (O) 2.9 S732 (OG) E1794 (OE2) 2.7
N734 (ND2) E1793 (OE2) 2.7 K733 (NZ) D1795 (OD1) 2.7
N735 (ND2) D1795 (OD1) 2.8 R1803 (NH1) P739 (O) 2.8
E738 (N) E1671 (O) 3.0 R1803 (NH2) E738 (OE2) 2.9
R740 (NH1) E1811 (OE1) 2.8 R1803 (NH2) P739 (O) 2.9
R740 (NH2) E738 (OE1) 2.7 K1804 (NZ) E738 (OE1) 2.7
R740 (NH2) E738 (OE2) 3.4 K1833 (NZ) Y664 (O) 2.8
S1669 (N) E738 (O) 3.1 K1833 (NZ) D666 (OD1) 2.8
S1669 (OG) E738 (OE2) 2.7 N1904 (ND2) N414 (O) 2.9
V 1670 (N) P739 (O) 3.2 N1904 (ND2) N414 (OD1) 3.0
E 1671 (N) E738 (O) 3.1 Q1906 (N) P606 (O) 3.0
D 1795 (N) N734 (OD1) 3.1 K1967 (NZ) E665 (OE1) 2.9
R 1797 (NH1) L687 (O) 3.0    
T 1826 (N) Y664 (OH) 3.1    
K 1833 (NZ) Y664 (O) 2.9    
K 1833 (NZ) D666 (OD1) 2.6    
R 1900 (N) E607 (OE1) 2.7    
A 1901 (N) E607 (OE1) 3.2    
Q 1906 (N) P606 (O) 2.8    
Q 1906 (NE2) E604 (OE1) 2.9    
K 1967 (NZ) E665 (OE1) 2.8