Evolutionarily conserved amino acid residues among MnmC. Conservation of each residue is mapped onto the ecMnmC structure where magenta represents highly conserved amino acids and light blue reflects variable regions. A) FAD binding site is centered where the cofactor is represented in green sticks. B) Enzyme is oriented to display the SAM binding site, where the ligand is shown in green sticks. Conservation score was calculated and presented by the ConSurf server .