Fig. 2

Alignment of seven vertebrate AQP8s together with the modeling templates AtTIP2;1 and EcAqpZ. Secondary structures as modelled in HsAQP8 are depicted beneath the multiple sequence alignment. The amino acids are colored according to their chemical properties. Residues that are part of the selectivity filter are depicted by vertical arrows: H2^P – black, LC^P – purple, H5^P – yellow, LE^P – green, HE^P – red. Black boxes mark regions in HsAQP8 that are modeled based on EcAqpZ. See also Table 1 and Additional file 2: Figure S2