Fig. 6
From: The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases
Interaction between TDP and TKT. Interactions between thiamine diphosphate (TDP) co-factor and the xylulose adduct, and residue sidechains and peptide backbone in the active site of TKT. Residues and backbone groups involved in hydrogen bonding, hydrophobic interactions and stacking interactions are indicated, based on the analysis of Tittmann and co-workers [6]. The equivalent residues in TKTL1 and TKTL2, based on the multiple alignment shown in Fig. 1, are indicated for each residue (order TKT, TKTL1 and TKTL2, top to bottom, in each square). Residues that are absent or not identical in the alignment are indicated