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Fig. 7 | BMC Structural Biology

Fig. 7

From: The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases

Fig. 7

Hydrophobic interactions with aminopyrimidine and thiazole rings. Association of thiamine diphosphate (TDP) with a hydrophobic nodule. The aminopyrimidine and thiazole rings (linked by a methylene bridge) is stabilized in a V-conformation by binding of the di-phosphate in a cavity, and association of a hydrophobic nodule formed by (a) L125 in TKT, (b) L95 in TKTL1, and (c) L126 in TKTL2, with ring structures. The molecular surface is shown colored according to the Kyte-Doolittle hydrophobic value in the range − 4.5 (purple) to 4.5 (tan)

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