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  1. Research article

    A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    BMC Structural Biology 2016 16:1

    Published on: 28 January 2016

  2. Research article

    The crystal structure of the Hazara virus nucleocapsid protein

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    BMC Structural Biology 2015 15:24

    Published on: 29 December 2015

  3. Research Article

    Clustering and percolation in protein loop structures

    High precision protein loop modelling remains a challenge, both in template based and template independent approaches to protein structure prediction.

    Xubiao Peng, Jianfeng He and Antti J. Niemi

    BMC Structural Biology 2015 15:22

    Published on: 29 October 2015

  4. Research article

    The origin of β-strand bending in globular proteins

    Many β-strands are not flat but bend and/or twist. However, although almost all β-strands have a twist, not all have a bend, suggesting that the underlying force(s) driving β-strand bending is distinct from th...

    Kazuo Fujiwara, Shinichi Ebisawa, Yuka Watanabe, Hiromi Fujiwara and Masamichi Ikeguchi

    BMC Structural Biology 2015 15:21

    Published on: 22 October 2015

  5. Research article

    An intact helical domain is required for Gα14 to stimulate phospholipase Cβ

    Stimulation of phospholipase Cβ (PLCβ) by the activated α-subunit of Gq (Gαq) constitutes a major signaling pathway for cellular regulation, and structural studies have recently revealed the molecular interaction...

    Dawna HT Kwan, Ka M. Wong, Anthony SL Chan, Lisa Y. Yung and Yung H. Wong

    BMC Structural Biology 2015 15:18

    Published on: 16 September 2015

  6. Research article

    The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins

    The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Dros...

    Sarin Chimnaronk, Jatuporn Sitthiroongruang, Kanokporn Srisucharitpanit, Monrudee Srisaisup, Albert J. Ketterman and Panadda Boonserm

    BMC Structural Biology 2015 15:17

    Published on: 16 September 2015

  7. Research article

    Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor

    Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface. Upstream of the catalytic domain of NanA is a domain that conforms to the s...

    Lei Yang, Helen Connaris, Jane A. Potter and Garry L. Taylor

    BMC Structural Biology 2015 15:15

    Published on: 20 August 2015

    The Erratum to this article has been published in BMC Structural Biology 2015 15:19

  8. Research article

    Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

    Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moie...

    Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh and Sylvie Garneau-Tsodikova

    BMC Structural Biology 2015 15:13

    Published on: 15 July 2015

  9. Research article

    Structure of the stationary phase survival protein YuiC from B.subtilis

    Stationary phase survival proteins (Sps) were found in Firmicutes as having analogous domain compositions, and in some cases genome context, as the resuscitation promoting factors of Actinobacteria, but with a...

    Doris H.X. Quay, Ambrose R. Cole, Adam Cryar, Konstantinos Thalassinos, Mark A. Williams, Sanjib Bhakta and Nicholas H. Keep

    BMC Structural Biology 2015 15:12

    Published on: 11 July 2015

  10. Research article

    Variations in periplasmic loop interactions determine the pH-dependent activity of the hexameric urea transporter UreI from Helicobacter pylori: a molecular dynamics study

    Helicobacter pylori is an important factor in the development of diseases such as ulcer and gastric cancer. This bacterium uses a periplasmic transporter, UreI, to deliver urea to the ...

    Javier Cáceres-Delpiano, Jaime Teneb, Rodrigo Mansilla, Apolinaria García and Alexis Salas-Burgos

    BMC Structural Biology 2015 15:11

    Published on: 26 June 2015

  11. Research article

    Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase

    Uracil-DNA glycosylases are evolutionarily conserved DNA repair enzymes. However, vaccinia virus uracil-DNA glycosylase (known as D4), also serves as an intrinsic and essential component of the processive DNA ...

    Norbert Schormann, Surajit Banerjee, Robert Ricciardi and Debasish Chattopadhyay

    BMC Structural Biology 2015 15:10

    Published on: 2 June 2015

  12. Research article

    Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies

    The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conse...

    Michael Berry, Burtram Fielding and Junaid Gamieldien

    BMC Structural Biology 2015 15:8

    Published on: 28 April 2015

  13. Research article

    High-resolution structure of a type IV pilin from the metal-reducing bacterium Shewanella oneidensis

    Type IV pili are widely expressed among Gram-negative bacteria, where they are involved in biofilm formation, serve in the transfer of DNA, motility and in the bacterial attachment to various surfaces. Type IV...

    Manuela Gorgel, Jakob Jensen Ulstrup, Andreas Bøggild, Nykola C Jones, Søren V Hoffmann, Poul Nissen and Thomas Boesen

    BMC Structural Biology 2015 15:4

    Published on: 27 February 2015

  14. Research article

    Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis

    Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modula...

    Plínio Salmazo Vieira, Priscila Oliveira de Giuseppe, Mario Tyago Murakami and Arthur Henrique Cavalcante de Oliveira

    BMC Structural Biology 2015 15:2

    Published on: 3 February 2015

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