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  1. Content type: Research article

    The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through t...

    Authors: Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg and Konstantin V. Korotkov

    Citation: BMC Structural Biology 2016 16:5

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  2. Content type: Software

    The term ‘molecular cartography’ encompasses a family of computational methods for two-dimensional transformation of protein structures and analysis of their physicochemical properties. The underlying algorith...

    Authors: Dimitrios Georgios Kontopoulos, Dimitrios Vlachakis, Georgia Tsiliki and Sofia Kossida

    Citation: BMC Structural Biology 2016 16:4

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    The Publisher's Erratum to this article has been published in BMC Structural Biology 2016 16:6

  3. Content type: Research Article

    The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative ...

    Authors: Yongbin Xu, Jianyun Guo, Xiaoling Jin, Jin-Sik Kim, Ying Ji, Shengdi Fan, Nam-Chul Ha and Chun-Shan Quan

    Citation: BMC Structural Biology 2016 16:3

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  4. Content type: Research article

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Authors: Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    Citation: BMC Structural Biology 2016 16:1

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  5. Content type: Research article

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Authors: Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    Citation: BMC Structural Biology 2015 15:24

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  6. Content type: Research article

    Protein-protein interactions (PPIs) mediate the vast majority of biological processes, therefore, significant efforts have been directed to investigate PPIs to fully comprehend cellular functions. Predicting c...

    Authors: Surabhi Maheshwari and Michal Brylinski

    Citation: BMC Structural Biology 2015 15:23

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  7. Content type: Research article

    Many β-strands are not flat but bend and/or twist. However, although almost all β-strands have a twist, not all have a bend, suggesting that the underlying force(s) driving β-strand bending is distinct from th...

    Authors: Kazuo Fujiwara, Shinichi Ebisawa, Yuka Watanabe, Hiromi Fujiwara and Masamichi Ikeguchi

    Citation: BMC Structural Biology 2015 15:21

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  8. Content type: Research article

    RNA ligases 2 are scarce and scattered across the tree of life. Two members of this family are well studied: the mitochondrial RNA editing ligase from the parasitic trypanosomes (Kinetoplastea), a promising dr...

    Authors: Sandrine Moreira, Emmanuel Noutahi, Guillaume Lamoureux and Gertraud Burger

    Citation: BMC Structural Biology 2015 15:20

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  9. Content type: Research article

    Stimulation of phospholipase Cβ (PLCβ) by the activated α-subunit of Gq (Gαq) constitutes a major signaling pathway for cellular regulation, and structural studies have recently revealed the molecular interaction...

    Authors: Dawna HT Kwan, Ka M. Wong, Anthony SL Chan, Lisa Y. Yung and Yung H. Wong

    Citation: BMC Structural Biology 2015 15:18

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  10. Content type: Research article

    The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Dros...

    Authors: Sarin Chimnaronk, Jatuporn Sitthiroongruang, Kanokporn Srisucharitpanit, Monrudee Srisaisup, Albert J. Ketterman and Panadda Boonserm

    Citation: BMC Structural Biology 2015 15:17

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  11. Content type: Research article

    Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface. Upstream of the catalytic domain of NanA is a domain that conforms to the s...

    Authors: Lei Yang, Helen Connaris, Jane A. Potter and Garry L. Taylor

    Citation: BMC Structural Biology 2015 15:15

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    The Erratum to this article has been published in BMC Structural Biology 2015 15:19

  12. Content type: Research article

    Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moie...

    Authors: Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh and Sylvie Garneau-Tsodikova

    Citation: BMC Structural Biology 2015 15:13

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  13. Content type: Research article

    Stationary phase survival proteins (Sps) were found in Firmicutes as having analogous domain compositions, and in some cases genome context, as the resuscitation promoting factors of Actinobacteria, but with a...

    Authors: Doris H.X. Quay, Ambrose R. Cole, Adam Cryar, Konstantinos Thalassinos, Mark A. Williams, Sanjib Bhakta and Nicholas H. Keep

    Citation: BMC Structural Biology 2015 15:12

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  14. Content type: Research article

    Helicobacter pylori is an important factor in the development of diseases such as ulcer and gastric cancer. This bacterium uses a periplasmic transporter, UreI, to deliver urea to the ...

    Authors: Javier Cáceres-Delpiano, Jaime Teneb, Rodrigo Mansilla, Apolinaria García and Alexis Salas-Burgos

    Citation: BMC Structural Biology 2015 15:11

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  15. Content type: Research article

    Uracil-DNA glycosylases are evolutionarily conserved DNA repair enzymes. However, vaccinia virus uracil-DNA glycosylase (known as D4), also serves as an intrinsic and essential component of the processive DNA ...

    Authors: Norbert Schormann, Surajit Banerjee, Robert Ricciardi and Debasish Chattopadhyay

    Citation: BMC Structural Biology 2015 15:10

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  16. Content type: Research article

    The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conse...

    Authors: Michael Berry, Burtram Fielding and Junaid Gamieldien

    Citation: BMC Structural Biology 2015 15:8

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  17. Content type: Research article

    Deinococcus radiodurans is an extremely radiation and desiccation resistant bacterium which can tolerate radiation doses up to 5,000 Grays without losing viability. We are studying the role of ...

    Authors: Laila Niiranen, Kjersti Lian, Kenneth A Johnson and Elin Moe

    Citation: BMC Structural Biology 2015 15:5

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  18. Content type: Research article

    Type IV pili are widely expressed among Gram-negative bacteria, where they are involved in biofilm formation, serve in the transfer of DNA, motility and in the bacterial attachment to various surfaces. Type IV...

    Authors: Manuela Gorgel, Jakob Jensen Ulstrup, Andreas Bøggild, Nykola C Jones, Søren V Hoffmann, Poul Nissen and Thomas Boesen

    Citation: BMC Structural Biology 2015 15:4

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  19. Content type: Research article

    Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modula...

    Authors: Plínio Salmazo Vieira, Priscila Oliveira de Giuseppe, Mario Tyago Murakami and Arthur Henrique Cavalcante de Oliveira

    Citation: BMC Structural Biology 2015 15:2

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  20. Content type: Research article

    Pig aldo-keto reductase family 1 member C1 (AKR1C1) belongs to AKR superfamily which catalyzes the NAD(P)H-dependent reduction of various substrates including steroid hormones. Previously we have reported two ...

    Authors: Minky Son, Chanin Park, Seul Gi Kwon, Woo Young Bang, Sam Woong Kim, Chul Wook Kim and Keun Woo Lee

    Citation: BMC Structural Biology 2015 15:1

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  21. Content type: Research article

    Hirudin is an anti-coagulation protein produced by the salivary glands of the medicinal leech Hirudomedicinalis. It is a powerful and specific thrombin inhibitor. The novel recombinant hirudin, RGD-hirudin, wh...

    Authors: Yinong Huang, Yanling Zhang, Bing Zhao, Qiping Xu, Xiushi Zhou, Houyan Song, Min Yu and Wei Mo

    Citation: BMC Structural Biology 2014 14:26

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  22. Content type: Research article

    Polymyxin B resistance protein D (PmrD) plays a key role in the polymyxin B-resistance pathway, as it is the signaling protein that can act as a specific connecter between PmrA/PmrB and PhoP/PhoQ. We conducted...

    Authors: Hunho Jo, Eui Young Jeong, Jinseong Jeon and Changill Ban

    Citation: BMC Structural Biology 2014 14:24

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  23. Content type: Research article

    Bacterial pyruvate decarboxylases (PDC) are rare. Their role in ethanol production and in bacterially mediated ethanologenic processes has, however, ensured a continued and growing interest. PDCs from Zymomonas m...

    Authors: Leonardo J van Zyl, Wolf-Dieter Schubert, Marla I Tuffin and Don A Cowan

    Citation: BMC Structural Biology 2014 14:21

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  24. Content type: Research Article

    Thanks to the growth in sequence and structure databases, more than 50 million sequences are now available in UniProt and 100,000 structures in the PDB. Rich information about protein-protein interfaces can be...

    Authors: Kumaran Baskaran, Jose M Duarte, Nikhil Biyani, Spencer Bliven and Guido Capitani

    Citation: BMC Structural Biology 2014 14:22

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  25. Content type: Research article

    The identification of the mechanisms of adaptation of protein structures to extreme environmental conditions is a challenging task of structural biology. We performed molecular dynamics (MD) simulations of the...

    Authors: Kirill E. Medvedev, Nikolay A. Alemasov, Yuri N. Vorobjev, Elena V. Boldyreva, Nikolay A. Kolchanov and Dmitry A. Afonnikov

    Citation: BMC Structural Biology 2014 14:23

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  26. Content type: Research article

    Despite the chloride anion is involved in fundamental biological processes, its interactions with proteins are little known. In particular, we lack a systematic survey of its coordination spheres.

    Authors: Oliviero Carugo

    Citation: BMC Structural Biology 2014 14:19

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  27. Content type: Research article

    This paper provides a simple and rapid method for a protein-clustering strategy. The basic idea implemented here is to use computational geometry methods to predict and characterize ligand-binding pockets of a...

    Authors: Seyed Majid Saberi Fathi and Jack A Tuszynski

    Citation: BMC Structural Biology 2014 14:18

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  28. Content type: Research article

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the s...

    Authors: Catherine N Leettola, Mary Jane Knight, Duilio Cascio, Sigrid Hoffman and James U Bowie

    Citation: BMC Structural Biology 2014 14:17

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  29. Content type: Research article

    EPR-based distance measurements between spin labels in proteins have become a valuable tool in structural biology. The direct translation of the experimental distances into structural information is however of...

    Authors: Nicole Florin, Olav Schiemann and Gregor Hagelueken

    Citation: BMC Structural Biology 2014 14:16

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  30. Content type: Research article

    The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reacti...

    Authors: Andrew M Ellisdon, Qingwei Zhang, Michelle A Henstridge, Travis K Johnson, Coral G Warr, Ruby HP Law and James C Whisstock

    Citation: BMC Structural Biology 2014 14:14

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  31. Content type: Research article

    Protein model quality assessment is an essential component of generating and using protein structural models. During the Tenth Critical Assessment of Techniques for Protein Structure Prediction (CASP10), we de...

    Authors: Renzhi Cao, Zheng Wang and Jianlin Cheng

    Citation: BMC Structural Biology 2014 14:13

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  32. Content type: Research article

    The multi-domain protein InlB (internalin B) from Listeria monocytogenes is an agonist of the human receptor tyrosine kinase MET. Only the internalin domain directly interacts with MET. The internalin domain cons...

    Authors: Dennis Breitsprecher, Ermanno Gherardi, Willem M Bleymüller and Hartmut H Niemann

    Citation: BMC Structural Biology 2014 14:12

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  33. Content type: Research article

    At least a quarter of any complete genome encodes for hypothetical proteins (HPs) which are largely non-similar to other known, well-characterized proteins. Predicting and solving their structures and function...

    Authors: Soo Huei Tan, Yahaya M Normi, Adam Thean Chor Leow, Abu Bakar Salleh, Roghayeh Abedi Karjiban, Abdul Munir Abdul Murad, Nor Muhammad Mahadi and Mohd Basyaruddin Abdul Rahman

    Citation: BMC Structural Biology 2014 14:11

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  34. Content type: Research article

    The ubiquitous non-receptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) plays a key role in RAS/ERK signaling downstream of most, if not all growth factors, cytokines and integrins, although its major s...

    Authors: Wei Qiu, Xiaonan Wang, Vladimir Romanov, Ashley Hutchinson, Andrés Lin, Maxim Ruzanov, Kevin P Battaile, Emil F Pai, Benjamin G Neel and Nickolay Y Chirgadze

    Citation: BMC Structural Biology 2014 14:10

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  35. Content type: Research article

    High-throughput mass spectrometric (HT-MS) study is the method of choice for monitoring global changes in proteome. Data derived from these studies are meant for further validation and experimentation to disco...

    Authors: Arun Kumar Somavarapu, Satish Balakrishnan, Amit Kumar Singh Gautam, David S Palmer and Prasanna Venkatraman

    Citation: BMC Structural Biology 2014 14:9

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  36. Content type: Research article

    Although many hyperthermophilic endoglucanases have been reported from archaea and bacteria, a complete survey and classification of all sequences in these species from disparate evolutionary groups, and the r...

    Authors: Hao Shi, Yu Zhang, Liangliang Wang, Xun Li, Wenqian Li, Fei Wang and Xiangqian Li

    Citation: BMC Structural Biology 2014 14:8

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  37. Content type: Research article

    Klebsiella pneumoniae plays a major role in causing nosocomial infection in immunocompromised patients. Medical inflictions by the pathogen can range from respiratory and urinary tract infections, septicemia and ...

    Authors: Boon Aun Teh, Sy Bing Choi, Nasihah Musa, Few Ling Ling, See Too Wei Cun, Abu Bakar Salleh, Nazalan Najimudin, Habibah A Wahab and Yahaya M Normi

    Citation: BMC Structural Biology 2014 14:7

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2017 Journal Metrics

  • Citation Impact
    1.308 - 2-year Impact Factor
    1.609 - 5-year Impact Factor
    0.643 - Source Normalized Impact per Paper (SNIP)
    1.024 - SCImago Journal Rank (SJR)


    Social Media Impact
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