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  1. PcrV is a hydrophilic translocator of type three secretion system (TTSS) and a structural component of the functional translocon. C-terminal helix of PcrV is essential for its oligomerization at the needle tip...

    Authors: Abhishek Basu, Urmisha Das, Supratim Dey and Saumen Datta

    Citation: BMC Structural Biology 2014 14:5

    Content type: Research article

    Published on:

  2. Many biologically active compounds bind to plasma transport proteins, and this binding can be either advantageous or disadvantageous from a drug design perspective. Human serum albumin (HSA) is one of the most...

    Authors: Annfrid Sivertsen, Johan Isaksson, Hanna-Kirsti S Leiros, Johan Svenson, John-Sigurd Svendsen and Bjørn Olav Brandsdal

    Citation: BMC Structural Biology 2014 14:4

    Content type: Research article

    Published on:

  3. Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies. Dysferlin is a type two-anchored membrane protein, wit...

    Authors: Altin Sula, Ambrose R Cole, Corin Yeats, Christine Orengo and Nicholas H Keep

    Citation: BMC Structural Biology 2014 14:3

    Content type: Research article

    Published on:

  4. p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones. Ho...

    Authors: Shasha Shi, Juanyu Lin, Yongfei Cai, Jiao Yu, Haiyan Hong, Kunmei Ji, Jennifer S Downey, Xiaodong Lu, Ruichuan Chen, Jiahuai Han and Aidong Han

    Citation: BMC Structural Biology 2014 14:2

    Content type: Research article

    Published on:

  5. 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol-2-phosphate to 2C-methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosph...

    Authors: Patrick EF O’Rourke, Justyna Kalinowska-Tłuścik, Paul K Fyfe, Alice Dawson and William N Hunter

    Citation: BMC Structural Biology 2014 14:1

    Content type: Research article

    Published on:

  6. Most of the proteins in the Protein Data Bank (PDB) are oligomeric complexes consisting of two or more subunits that associate by rotational or helical symmetries. Despite the myriad of superimposition tools i...

    Authors: Manuel Rueda, Modesto Orozco, Maxim Totrov and Ruben Abagyan

    Citation: BMC Structural Biology 2013 13:32

    Content type: Software

    Published on:

  7. S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions. Biochemical stud...

    Authors: Udupi A Ramagopal, Natalya G Dulyaninova, Kristen M Varney, Paul T Wilder, Sridevi Nallamsetty, Michael Brenowitz, David J Weber, Steven C Almo and Anne R Bresnick

    Citation: BMC Structural Biology 2013 13:31

    Content type: Research article

    Published on:

  8. para-Nitrophenol (PNP) is a highly toxic compound with threats to mammalian health. The pnpE-encoded γ-hydroxymuconic semialdehyde dehydrogenase catalyzes the reduction of γ-hydroxymuconic semialdehyde to maleyl...

    Authors: Jing Su, Cong Zhang, Jun-Jie Zhang, Tiandi Wei, Deyu Zhu, Ning-Yi Zhou and Li chuan Gu

    Citation: BMC Structural Biology 2013 13:30

    Content type: Research article

    Published on:

  9. Malyl-CoA lyase (MCL) is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related Coenzyme A (CoA) thioesters. This enzyme plays a crucial, multifunctional role in ...

    Authors: Jan Zarzycki and Cheryl A Kerfeld

    Citation: BMC Structural Biology 2013 13:28

    Content type: Research article

    Published on:

  10. Using the popular program AutoDock, computer-aided docking of small ligands with 6 or fewer rotatable bonds, is reasonably fast and accurate. However, docking large ligands using AutoDock's recommended standar...

    Authors: Ankur Dhanik, John S McMurray and Lydia E Kavraki

    Citation: BMC Structural Biology 2013 13(Suppl 1):S11

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  11. Conformational flexibility creates errors in the comparison of protein structures. Even small changes in backbone or sidechain conformation can radically alter the shape of ligand binding cavities. These chang...

    Authors: Brian G Godshall, Yisheng Tang, Wenjie Yang and Brian Y Chen

    Citation: BMC Structural Biology 2013 13(Suppl 1):S10

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  12. Protein loops are flexible structures that are intimately tied to function, but understanding loop motion and generating loop conformation ensembles remain significant computational challenges. Discrete search...

    Authors: Yajia Zhang and Kris Hauser

    Citation: BMC Structural Biology 2013 13(Suppl 1):S9

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  13. Many proteins tune their biological function by transitioning between different functional states, effectively acting as dynamic molecular machines. Detailed structural characterization of transition trajector...

    Authors: Kevin Molloy and Amarda Shehu

    Citation: BMC Structural Biology 2013 13(Suppl 1):S8

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  14. We introduce a protein docking refinement method that accepts complexes consisting of any number of monomeric units. The method uses a scoring function based on a tight coupling between evolutionary conservati...

    Authors: Bahar Akbal-Delibas and Nurit Haspel

    Citation: BMC Structural Biology 2013 13(Suppl 1):S7

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  15. Certain amino acids in proteins play a critical role in determining their structural stability and function. Examples include flexible regions such as hinges which allow domain motion, and highly conserved res...

    Authors: Bahar Akbal-Delibas, Filip Jagodzinski and Nurit Haspel

    Citation: BMC Structural Biology 2013 13(Suppl 1):S6

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  16. De novo protein modeling approaches utilize 3-dimensional (3D) images derived from electron cryomicroscopy (CryoEM) experiments. The skeleton connecting two secondary structures such as α-helices represent the lo...

    Authors: Andrew McKnight, Dong Si, Kamal Al Nasr, Andrey Chernikov, Nikos Chrisochoides and Jing He

    Citation: BMC Structural Biology 2013 13(Suppl 1):S5

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  17. Elucidating the native structure of a protein molecule from its sequence of amino acids, a problem known as de novo structure prediction, is a long standing challenge in computational structural biology. Diffi...

    Authors: Sameh Saleh, Brian Olson and Amarda Shehu

    Citation: BMC Structural Biology 2013 13(Suppl 1):S4

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  18. Ribonucleic acid (RNA) molecules play important roles in many biological processes including gene expression and regulation. Their secondary structures are crucial for the RNA functionality, and the prediction...

    Authors: Boyu Zhang, Daniel T Yehdego, Kyle L Johnson, Ming-Ying Leung and Michela Taufer

    Citation: BMC Structural Biology 2013 13(Suppl 1):S3

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  19. Obtaining atomic-scale information about large-amplitude conformational transitions in proteins is a challenging problem for both experimental and computational methods. Such information is, however, important...

    Authors: Ibrahim Al-Bluwi, Marc Vaisset, Thierry Siméon and Juan Cortés

    Citation: BMC Structural Biology 2013 13(Suppl 1):S2

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  20. Models that are capable of reliably predicting binding affinities for protein-ligand complexes play an important role the field of structure-guided drug design.

    Authors: Majid Masso

    Citation: BMC Structural Biology 2013 13(Suppl 1):S1

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  21. Resveratrol, a naturally occurring stilbene, has been categorized as a phytoestrogen due to its ability to compete with natural estrogens for binding to estrogen receptor alpha (ERα) and modulate the biologica...

    Authors: Sandipan Chakraborty, Anait S Levenson and Pradip K Biswas

    Citation: BMC Structural Biology 2013 13:27

    Content type: Research article

    Published on:

  22. Pyridoxal 5′-phosphate (PLP)-dependent enzymes of fold type I, the most studied structural class of the PLP-dependent enzyme superfamily, are known to exist as stand-alone homodimers or homotetramers. These en...

    Authors: Teresa Milano, Alessandro Paiardini, Ingeborg Grgurina and Stefano Pascarella

    Citation: BMC Structural Biology 2013 13:26

    Content type: Research article

    Published on:

  23. Picking images of particles in cryo-electron micrographs is an important step in solving the 3D structures of large macromolecular assemblies. However, in order to achieve sub-nanometre resolution it is often ...

    Authors: Thai V Hoang, Xavier Cavin, Patrick Schultz and David W Ritchie

    Citation: BMC Structural Biology 2013 13:25

    Content type: Software

    Published on:

  24. Protein Structure Initiative:Biology (PSI:Biology) is the third phase of PSI where protein structures are determined in high-throughput to characterize their biological functions. The transition to the third p...

    Authors: Paul J DePietro, Elchin S Julfayev and William A McLaughlin

    Citation: BMC Structural Biology 2013 13:24

    Content type: Research article

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  25. Bacterial D is ulfide b ond forming (Dsb) proteins facilitate proper folding and disulfide bond formation of periplasmic and secreted proteins. Previously, we have shown that Mycobacterium tuberculosis Mt-DsbE an...

    Authors: Nicholas Chim, Christine A Harmston, David J Guzman and Celia W Goulding

    Citation: BMC Structural Biology 2013 13:23

    Content type: Research article

    Published on:

  26. Methionine adenosyltransferases catalyse the synthesis of S-adenosylmethionine, a cofactor abundant in all domains of life. In contrast to the enzymes from bacteria and eukarya that show high sequence similarity,...

    Authors: Julia Schlesier, Jutta Siegrist, Stefan Gerhardt, Annette Erb, Simone Blaesi, Michael Richter, Oliver Einsle and Jennifer N Andexer

    Citation: BMC Structural Biology 2013 13:22

    Content type: Research article

    Published on:

  27. The amount of transmembrane protein (TM) structures solved to date is now large enough to attempt large scale analyses. In particular, extensive studies of oligomeric interfaces in the transmembrane region are...

    Authors: Jose M Duarte, Nikhil Biyani, Kumaran Baskaran and Guido Capitani

    Citation: BMC Structural Biology 2013 13:21

    Content type: Research article

    Published on:

  28. Assessing protein modularity is important to understand protein evolution. Still the question of the existence of a sub-domain modular architecture remains. We propose a graph-theory approach with significance...

    Authors: Jose Sergio Hleap, Edward Susko and Christian Blouin

    Citation: BMC Structural Biology 2013 13:20

    Content type: Methodology article

    Published on:

  29. Increasing rates of antimicrobial resistance among uropathogens led, among other efforts, to the application of subtractive reverse vaccinology for the identification of antigens present in extraintestinal pat...

    Authors: Dunja Urosev, Mario Ferrer-Navarro, Ilaria Pastorello, Elena Cartocci, Lionel Costenaro, Dmitrijs Zhulenkovs, Jean-Didier Maréchal, Ainars Leonchiks, David Reverter, Laura Serino, Marco Soriani and Xavier Daura

    Citation: BMC Structural Biology 2013 13:19

    Content type: Research article

    Published on:

  30. Members of the periplasmic binding protein (PBP) superfamily utilize a highly conserved inter-domain ligand binding site that adapts to specifically bind a chemically diverse range of ligands. This paradigm of...

    Authors: Parthapratim Munshi, Christopher B Stanley, Sudipa Ghimire-Rijal, Xun Lu, Dean A Myles and Matthew J Cuneo

    Citation: BMC Structural Biology 2013 13:18

    Content type: Research article

    Published on:

  31. The human mineralocorticoid receptor (MR) is one of the main components of the renin-angiotensin-aldosterone system (RAAS), the system that regulates the body exchange of water and sodium. The evolutionary ori...

    Authors: Metaxia Vlassi, Katharina Brauns and Miguel A Andrade-Navarro

    Citation: BMC Structural Biology 2013 13:17

    Content type: Research article

    Published on:

  32. Persistent organic pollutants (POPs) are persistent in the environment after release from industrial compounds, combustion productions or pesticides. The exposure of POPs has been related to various reproducti...

    Authors: Xian Jin Xu, Ji Guo Su, Anna Rita Bizzarri, Salvatore Cannistraro, Ming Liu, Yi Zeng, Wei Zu Chen and Cun Xin Wang

    Citation: BMC Structural Biology 2013 13:16

    Content type: Research article

    Published on:

  33. The arginine of the D/E/NRY motif in Rhodopsin family G protein-coupled receptors (GPCRs) is conserved in 96% of these proteins. In some GPCRs, this arginine in transmembrane 3 can form a salt bridge with an a...

    Authors: Margaret M Pruitt, Monica H Lamm and Clark R Coffman

    Citation: BMC Structural Biology 2013 13:15

    Content type: Research article

    Published on:

  34. Retroviral integrases (INs) catalyze the integration of viral DNA in the chromosomal DNA of the infected cell. This reaction requires the multimerization of IN to coordinate a nucleophilic attack of the 3’ end...

    Authors: Daniel R Henriquez, Caifeng Zhao, Haiyan Zheng, José J Arbildua, Mónica L Acevedo, Monica J Roth and Oscar Leon

    Citation: BMC Structural Biology 2013 13:14

    Content type: Research article

    Published on:

  35. Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRPγ is expressed on T lymphocytes where it ...

    Authors: Joanne E Nettleship, Jingshan Ren, David J Scott, Nahid Rahman, Deborah Hatherley, Yuguang Zhao, David I Stuart, A Neil Barclay and Raymond J Owens

    Citation: BMC Structural Biology 2013 13:13

    Content type: Research article

    Published on:

  36. Strict regulation of replisome components is essential to ensure the accurate transmission of the genome to the next generation. The sliding clamp processivity factors play a central role in this regulation, i...

    Authors: Atif A Patoli, Jody A Winter and Karen A Bunting

    Citation: BMC Structural Biology 2013 13:12

    Content type: Research article

    Published on:

  37. Protein N-glycosylation occurs in the three domains of life. Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the asparagine residue in the N-glycosylation sequons. The catalytic subunits ...

    Authors: Shunsuke Matsumoto, Atsushi Shimada and Daisuke Kohda

    Citation: BMC Structural Biology 2013 13:11

    Content type: Research article

    Published on:

  38. In the anaerobic pathway of cobalamin (vitamin B12) synthesis, the CbiT enzyme plays two roles, as a cobalt-precorrin-7 C15-methyltransferase and a C12-decarboxylase, to produce the intermediate, cobalt-precorrin...

    Authors: Balasundaram Padmanabhan, Shigeyuki Yokoyama and Yoshitaka Bessho

    Citation: BMC Structural Biology 2013 13:10

    Content type: Research article

    Published on:

  39. Mutation of amino acid sequences in a protein may have diverse effects on its structure and function. Point mutations of even a single amino acid residue in the helices of the non-redundant database may lead t...

    Authors: Nicholus Bhattacharjee and Parbati Biswas

    Citation: BMC Structural Biology 2013 13:9

    Content type: Research article

    Published on:

  40. In addition to the core catalytic machinery, bacterial replicative DNA polymerases contain a Polymerase and Histidinol Phosphatase (PHP) domain whose function is not entirely understood. The PHP domains of som...

    Authors: Tiago Barros, Joel Guenther, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O’Donnell, John Kuriyan and Meindert H Lamers

    Citation: BMC Structural Biology 2013 13:8

    Content type: Research article

    Published on:

  41. The Multidrug Resistance Protein ABCC11/MRP8 is expressed in physiological barriers and tumor breast tissues in which it secretes various substrates including cGMP (cyclic guanosine monophosphate) and 5FdUMP (...

    Authors: Mylène Honorat, Raphaël Terreux, Pierre Falson, Attilio Di Pietro, Charles Dumontet and Lea Payen

    Citation: BMC Structural Biology 2013 13:7

    Content type: Research article

    Published on:

  42. The post-genomic era poses several challenges. The biggest is the identification of biochemical function for protein sequences and structures resulting from genomic initiatives. Most sequences lack a character...

    Authors: Rajaram Gana, Shruti Rao, Hongzhan Huang, Cathy Wu and Sona Vasudevan

    Citation: BMC Structural Biology 2013 13:6

    Content type: Research article

    Published on:

  43. To explore novel platinum-based anticancer agents that are distinct from the structure and interaction mode of the traditional cisplatin by forming the bifunctional intrastrand 1,2 GpG adduct, the monofunction...

    Authors: Shanshan Cui, Yan Wang and Guangju Chen

    Citation: BMC Structural Biology 2013 13:4

    Content type: Research article

    Published on:

  44. The CWxP motif of transmembrane helix 6 (x: any residue) is highly conserved in class A GPCRs. Within this motif, W6.48 is a big star in the theory of the global “toggle switch” because of its key role in the ...

    Authors: Mireia Olivella, Gianluigi Caltabiano and Arnau Cordomí

    Citation: BMC Structural Biology 2013 13:3

    Content type: Research article

    Published on:

2017 Journal Metrics

  • Citation Impact
    1.308 - 2-year Impact Factor
    1.609 - 5-year Impact Factor
    0.643 - Source Normalized Impact per Paper (SNIP)
    1.024 - SCImago Journal Rank (SJR)

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