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This section incorporates all aspects of the structural analysis of biological macromolecules using techniques in crystallography including but not limited to: studies incorporating substantial analysis by X-ray crystallography, X-ray diffraction, crystallization and/or protein expression and assays.

  1. Content type: Research article

    Ribose-phosphate pyrophosphokinase (EC is an enzyme that catalyzes the ATP-dependent conversion of ribose-5-phosphate to phosphoribosyl pyrophosphate. The reaction product is a key precursor for the b...

    Authors: Weijie Zhou, Andrew Tsai, Devon A. Dattmore, Devin P. Stives, Iva Chitrakar, Alexis M. D’alessandro, Shiv Patil, Katherine A. Hicks and Jarrod B. French

    Citation: BMC Structural Biology 2019 19:1

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  2. Content type: Research article

    The pathogenic yeast Candida albicans can proliferate in environments with different carbon dioxide concentrations thanks to the carbonic anhydrase CaNce103p, which accelerates spontaneous conversion of carbon di...

    Authors: Jiří Dostál, Jiří Brynda, Jan Blaha, Stanislav Macháček, Olga Heidingsfeld and Iva Pichová

    Citation: BMC Structural Biology 2018 18:14

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  3. Content type: Research article

    Lysozyme purified from duck eggs (DEL) has long been used as a model antigen as a counterpoint to the enzyme purified from hen eggs (HEL). However, unlike the single C-type variant found in hen eggs, duck eggs...

    Authors: David B. Langley and Daniel Christ

    Citation: BMC Structural Biology 2018 18:10

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  4. Content type: Research article

    Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-sp...

    Authors: Saara Laulumaa, Tuomo Nieminen, Arne Raasakka, Oda C. Krokengen, Anushik Safaryan, Erik I. Hallin, Guillaume Brysbaert, Marc F. Lensink, Salla Ruskamo, Ilpo Vattulainen and Petri Kursula

    Citation: BMC Structural Biology 2018 18:8

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  5. Content type: Database

    More than 7000 papers related to “protein refolding” have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for...

    Authors: Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura and Kei Yura

    Citation: BMC Structural Biology 2017 17:4

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  6. Content type: Methodology article

    Post-crystallization dehydration methods, applying either vapor diffusion or humidity control devices, have been widely used to improve the diffraction quality of protein crystals. Despite the fact that RNA cr...

    Authors: HaJeung Park, Tuan Tran, Jun Hyuck Lee, Hyun Park and Matthew D. Disney

    Citation: BMC Structural Biology 2016 16:19

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  7. Content type: Research article

    Diversity-generating retroelements (DGRs) provide organisms with a unique means for adaptation to a dynamic environment through massive protein sequence variation. The potential scope of this variation exceeds...

    Authors: Sumit Handa, Blair G. Paul, Jeffery F. Miller, David L. Valentine and Partho Ghosh

    Citation: BMC Structural Biology 2016 16:13

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  8. Content type: Research article

    S100 proteins are a large family of calcium binding proteins present only in vertebrates. They function intra- and extracellularly both as regulators of homeostatic processes and as potent effectors during inf...

    Authors: Haili Lin, Gregers Rom Andersen and Laure Yatime

    Citation: BMC Structural Biology 2016 16:8

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  9. Content type: Research article

    The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of the pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis,...

    Authors: Douglas J. Marcotte, YuTing Liu, Kevin Little, John H. Jones, Noel A. Powell, Craig P. Wildes, Laura F. Silvian and Jayanth V. Chodaparambil

    Citation: BMC Structural Biology 2016 16:7

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  10. Content type: Research article

    The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through t...

    Authors: Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg and Konstantin V. Korotkov

    Citation: BMC Structural Biology 2016 16:5

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  11. Content type: Research Article

    The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative ...

    Authors: Yongbin Xu, Jianyun Guo, Xiaoling Jin, Jin-Sik Kim, Ying Ji, Shengdi Fan, Nam-Chul Ha and Chun-Shan Quan

    Citation: BMC Structural Biology 2016 16:3

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  12. Content type: Research article

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Authors: Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    Citation: BMC Structural Biology 2016 16:1

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  13. Content type: Research article

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Authors: Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    Citation: BMC Structural Biology 2015 15:24

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  14. Content type: Research article

    Stimulation of phospholipase Cβ (PLCβ) by the activated α-subunit of Gq (Gαq) constitutes a major signaling pathway for cellular regulation, and structural studies have recently revealed the molecular interaction...

    Authors: Dawna HT Kwan, Ka M. Wong, Anthony SL Chan, Lisa Y. Yung and Yung H. Wong

    Citation: BMC Structural Biology 2015 15:18

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  15. Content type: Research article

    The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Dros...

    Authors: Sarin Chimnaronk, Jatuporn Sitthiroongruang, Kanokporn Srisucharitpanit, Monrudee Srisaisup, Albert J. Ketterman and Panadda Boonserm

    Citation: BMC Structural Biology 2015 15:17

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  16. Content type: Research article

    Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface. Upstream of the catalytic domain of NanA is a domain that conforms to the s...

    Authors: Lei Yang, Helen Connaris, Jane A. Potter and Garry L. Taylor

    Citation: BMC Structural Biology 2015 15:15

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    The Erratum to this article has been published in BMC Structural Biology 2015 15:19

  17. Content type: Research article

    Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moie...

    Authors: Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh and Sylvie Garneau-Tsodikova

    Citation: BMC Structural Biology 2015 15:13

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  18. Content type: Research article

    Stationary phase survival proteins (Sps) were found in Firmicutes as having analogous domain compositions, and in some cases genome context, as the resuscitation promoting factors of Actinobacteria, but with a...

    Authors: Doris H.X. Quay, Ambrose R. Cole, Adam Cryar, Konstantinos Thalassinos, Mark A. Williams, Sanjib Bhakta and Nicholas H. Keep

    Citation: BMC Structural Biology 2015 15:12

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  19. Content type: Research article

    Polymyxin B resistance protein D (PmrD) plays a key role in the polymyxin B-resistance pathway, as it is the signaling protein that can act as a specific connecter between PmrA/PmrB and PhoP/PhoQ. We conducted...

    Authors: Hunho Jo, Eui Young Jeong, Jinseong Jeon and Changill Ban

    Citation: BMC Structural Biology 2014 14:24

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  20. Content type: Research article

    Bacterial pyruvate decarboxylases (PDC) are rare. Their role in ethanol production and in bacterially mediated ethanologenic processes has, however, ensured a continued and growing interest. PDCs from Zymomonas m...

    Authors: Leonardo J van Zyl, Wolf-Dieter Schubert, Marla I Tuffin and Don A Cowan

    Citation: BMC Structural Biology 2014 14:21

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  21. Content type: Research article

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the s...

    Authors: Catherine N Leettola, Mary Jane Knight, Duilio Cascio, Sigrid Hoffman and James U Bowie

    Citation: BMC Structural Biology 2014 14:17

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  22. Content type: Research article

    EPR-based distance measurements between spin labels in proteins have become a valuable tool in structural biology. The direct translation of the experimental distances into structural information is however of...

    Authors: Nicole Florin, Olav Schiemann and Gregor Hagelueken

    Citation: BMC Structural Biology 2014 14:16

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  23. Content type: Research article

    The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reacti...

    Authors: Andrew M Ellisdon, Qingwei Zhang, Michelle A Henstridge, Travis K Johnson, Coral G Warr, Ruby HP Law and James C Whisstock

    Citation: BMC Structural Biology 2014 14:14

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  24. Content type: Research article

    The multi-domain protein InlB (internalin B) from Listeria monocytogenes is an agonist of the human receptor tyrosine kinase MET. Only the internalin domain directly interacts with MET. The internalin domain cons...

    Authors: Dennis Breitsprecher, Ermanno Gherardi, Willem M Bleymüller and Hartmut H Niemann

    Citation: BMC Structural Biology 2014 14:12

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  25. Content type: Research article

    The ubiquitous non-receptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) plays a key role in RAS/ERK signaling downstream of most, if not all growth factors, cytokines and integrins, although its major s...

    Authors: Wei Qiu, Xiaonan Wang, Vladimir Romanov, Ashley Hutchinson, Andrés Lin, Maxim Ruzanov, Kevin P Battaile, Emil F Pai, Benjamin G Neel and Nickolay Y Chirgadze

    Citation: BMC Structural Biology 2014 14:10

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  26. Content type: Research article

    Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies. Dysferlin is a type two-anchored membrane protein, wit...

    Authors: Altin Sula, Ambrose R Cole, Corin Yeats, Christine Orengo and Nicholas H Keep

    Citation: BMC Structural Biology 2014 14:3

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  27. Content type: Research article

    p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones. Ho...

    Authors: Shasha Shi, Juanyu Lin, Yongfei Cai, Jiao Yu, Haiyan Hong, Kunmei Ji, Jennifer S Downey, Xiaodong Lu, Ruichuan Chen, Jiahuai Han and Aidong Han

    Citation: BMC Structural Biology 2014 14:2

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  28. Content type: Research article

    2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol-2-phosphate to 2C-methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosph...

    Authors: Patrick EF O’Rourke, Justyna Kalinowska-Tłuścik, Paul K Fyfe, Alice Dawson and William N Hunter

    Citation: BMC Structural Biology 2014 14:1

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  29. Content type: Research article

    S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions. Biochemical stud...

    Authors: Udupi A Ramagopal, Natalya G Dulyaninova, Kristen M Varney, Paul T Wilder, Sridevi Nallamsetty, Michael Brenowitz, David J Weber, Steven C Almo and Anne R Bresnick

    Citation: BMC Structural Biology 2013 13:31

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  30. Content type: Research article

    para-Nitrophenol (PNP) is a highly toxic compound with threats to mammalian health. The pnpE-encoded γ-hydroxymuconic semialdehyde dehydrogenase catalyzes the reduction of γ-hydroxymuconic semialdehyde to maleyl...

    Authors: Jing Su, Cong Zhang, Jun-Jie Zhang, Tiandi Wei, Deyu Zhu, Ning-Yi Zhou and Li chuan Gu

    Citation: BMC Structural Biology 2013 13:30

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  31. Content type: Research article

    Malyl-CoA lyase (MCL) is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related Coenzyme A (CoA) thioesters. This enzyme plays a crucial, multifunctional role in ...

    Authors: Jan Zarzycki and Cheryl A Kerfeld

    Citation: BMC Structural Biology 2013 13:28

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  32. Content type: Research article

    Bacterial D is ulfide b ond forming (Dsb) proteins facilitate proper folding and disulfide bond formation of periplasmic and secreted proteins. Previously, we have shown that Mycobacterium tuberculosis Mt-DsbE an...

    Authors: Nicholas Chim, Christine A Harmston, David J Guzman and Celia W Goulding

    Citation: BMC Structural Biology 2013 13:23

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  33. Content type: Research article

    Methionine adenosyltransferases catalyse the synthesis of S-adenosylmethionine, a cofactor abundant in all domains of life. In contrast to the enzymes from bacteria and eukarya that show high sequence similarity,...

    Authors: Julia Schlesier, Jutta Siegrist, Stefan Gerhardt, Annette Erb, Simone Blaesi, Michael Richter, Oliver Einsle and Jennifer N Andexer

    Citation: BMC Structural Biology 2013 13:22

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  34. Content type: Research article

    Increasing rates of antimicrobial resistance among uropathogens led, among other efforts, to the application of subtractive reverse vaccinology for the identification of antigens present in extraintestinal pat...

    Authors: Dunja Urosev, Mario Ferrer-Navarro, Ilaria Pastorello, Elena Cartocci, Lionel Costenaro, Dmitrijs Zhulenkovs, Jean-Didier Maréchal, Ainars Leonchiks, David Reverter, Laura Serino, Marco Soriani and Xavier Daura

    Citation: BMC Structural Biology 2013 13:19

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  35. Content type: Research article

    Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRPγ is expressed on T lymphocytes where it ...

    Authors: Joanne E Nettleship, Jingshan Ren, David J Scott, Nahid Rahman, Deborah Hatherley, Yuguang Zhao, David I Stuart, A Neil Barclay and Raymond J Owens

    Citation: BMC Structural Biology 2013 13:13

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  36. Content type: Research article

    Strict regulation of replisome components is essential to ensure the accurate transmission of the genome to the next generation. The sliding clamp processivity factors play a central role in this regulation, i...

    Authors: Atif A Patoli, Jody A Winter and Karen A Bunting

    Citation: BMC Structural Biology 2013 13:12

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  37. Content type: Research article

    Protein N-glycosylation occurs in the three domains of life. Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the asparagine residue in the N-glycosylation sequons. The catalytic subunits ...

    Authors: Shunsuke Matsumoto, Atsushi Shimada and Daisuke Kohda

    Citation: BMC Structural Biology 2013 13:11

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  38. Content type: Research article

    In the anaerobic pathway of cobalamin (vitamin B12) synthesis, the CbiT enzyme plays two roles, as a cobalt-precorrin-7 C15-methyltransferase and a C12-decarboxylase, to produce the intermediate, cobalt-precorrin...

    Authors: Balasundaram Padmanabhan, Shigeyuki Yokoyama and Yoshitaka Bessho

    Citation: BMC Structural Biology 2013 13:10

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  39. Content type: Research article

    In addition to the core catalytic machinery, bacterial replicative DNA polymerases contain a Polymerase and Histidinol Phosphatase (PHP) domain whose function is not entirely understood. The PHP domains of som...

    Authors: Tiago Barros, Joel Guenther, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O’Donnell, John Kuriyan and Meindert H Lamers

    Citation: BMC Structural Biology 2013 13:8

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  40. Content type: Research article

    Human farnesyl pyrophosphate synthase (FPPS) controls intracellular levels of farnesyl pyrophosphate, which is essential for various biological processes. Bisphosphonate inhibitors of human FPPS are valuable t...

    Authors: Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos and Albert M Berghuis

    Citation: BMC Structural Biology 2012 12:32

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  41. Content type: Research article

    Bacteria such as Escherichia coli and Salmonella typhimurium can utilize acetate as the sole source of carbon and energy. Acetate kinase (AckA) and phosphotransacetylase (Pta), key enzymes of acetate utilization ...

    Authors: Sagar Chittori, Handanahal S Savithri and Mathur RN Murthy

    Citation: BMC Structural Biology 2012 12:24

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  42. Content type: Research article

    HutZ is the sole heme storage protein identified in the pathogenic bacterium Vibrio cholerae and is required for optimal heme utilization. However, no heme oxygenase activity has been observed with this protein. ...

    Authors: Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu and Lichuan Gu

    Citation: BMC Structural Biology 2012 12:23

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  43. Content type: Research article

    Structure-based drug design (SBDD) can accelerate inhibitor lead design and optimization, and efficient methods including protein purification, characterization, crystallization, and high-resolution diffractio...

    Authors: Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St John Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart…

    Citation: BMC Structural Biology 2012 12:22

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  44. Content type: Research article

    S100 proteins are a family of small, EF-hand containing calcium-binding signaling proteins that are implicated in many cancers. While the majority of human S100 proteins share 25-65% sequence similarity, S100A...

    Authors: Jill I Murray, Michelle L Tonkin, Amanda L Whiting, Fangni Peng, Benjamin Farnell, Jay T Cullen, Fraser Hof and Martin J Boulanger

    Citation: BMC Structural Biology 2012 12:16

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  45. Content type: Research article

    Dihydroxylation of tandemly linked aromatic carbons in a cis-configuration, catalyzed by multicomponent oxygenase systems known as Rieske nonheme iron oxygenase systems (ROs), often constitute the initial step of...

    Authors: Yuji Ashikawa, Zui Fujimoto, Yusuke Usami, Kengo Inoue, Haruko Noguchi, Hisakazu Yamane and Hideaki Nojiri

    Citation: BMC Structural Biology 2012 12:15

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  46. Content type: Research article

    Type III secretion systems are used by Gram-negative bacteria as “macromolecular syringes” to inject effector proteins into eukaryotic cells. Two hydrophobic proteins called translocators form the necessary po...

    Authors: Madeleine Schreiner and Hartmut H Niemann

    Citation: BMC Structural Biology 2012 12:13

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2017 Journal Metrics

  • Citation Impact
    1.308 - 2-year Impact Factor
    1.609 - 5-year Impact Factor
    0.643 - Source Normalized Impact per Paper (SNIP)
    1.024 - SCImago Journal Rank (SJR)


    Social Media Impact
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