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BMC Structural Biology

Crystallography

This section incorporates all aspects of the structural analysis of biological macromolecules using techniques in crystallography including but not limited to: studies incorporating substantial analysis by X-ray crystallography, X-ray diffraction, crystallization and/or protein expression and assays.

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  1. Content type: Database

    More than 7000 papers related to “protein refolding” have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for...

    Authors: Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura and Kei Yura

    Citation: BMC Structural Biology 2017 17:4

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  2. Content type: Methodology article

    Post-crystallization dehydration methods, applying either vapor diffusion or humidity control devices, have been widely used to improve the diffraction quality of protein crystals. Despite the fact that RNA cr...

    Authors: HaJeung Park, Tuan Tran, Jun Hyuck Lee, Hyun Park and Matthew D. Disney

    Citation: BMC Structural Biology 2016 16:19

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  3. Content type: Research article

    Diversity-generating retroelements (DGRs) provide organisms with a unique means for adaptation to a dynamic environment through massive protein sequence variation. The potential scope of this variation exceeds...

    Authors: Sumit Handa, Blair G. Paul, Jeffery F. Miller, David L. Valentine and Partho Ghosh

    Citation: BMC Structural Biology 2016 16:13

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  4. Content type: Research article

    S100 proteins are a large family of calcium binding proteins present only in vertebrates. They function intra- and extracellularly both as regulators of homeostatic processes and as potent effectors during inf...

    Authors: Haili Lin, Gregers Rom Andersen and Laure Yatime

    Citation: BMC Structural Biology 2016 16:8

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  5. Content type: Research article

    The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of the pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis,...

    Authors: Douglas J. Marcotte, YuTing Liu, Kevin Little, John H. Jones, Noel A. Powell, Craig P. Wildes, Laura F. Silvian and Jayanth V. Chodaparambil

    Citation: BMC Structural Biology 2016 16:7

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  6. Content type: Research article

    The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through t...

    Authors: Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg and Konstantin V. Korotkov

    Citation: BMC Structural Biology 2016 16:5

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  7. Content type: Research Article

    The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative ...

    Authors: Yongbin Xu, Jianyun Guo, Xiaoling Jin, Jin-Sik Kim, Ying Ji, Shengdi Fan, Nam-Chul Ha and Chun-Shan Quan

    Citation: BMC Structural Biology 2016 16:3

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  8. Content type: Research article

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Authors: Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    Citation: BMC Structural Biology 2016 16:1

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  9. Content type: Research article

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Authors: Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    Citation: BMC Structural Biology 2015 15:24

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  10. Content type: Research article

    Stimulation of phospholipase Cβ (PLCβ) by the activated α-subunit of Gq (Gαq) constitutes a major signaling pathway for cellular regulation, and structural studies have recently revealed the molecular interaction...

    Authors: Dawna HT Kwan, Ka M. Wong, Anthony SL Chan, Lisa Y. Yung and Yung H. Wong

    Citation: BMC Structural Biology 2015 15:18

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  11. Content type: Research article

    The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Dros...

    Authors: Sarin Chimnaronk, Jatuporn Sitthiroongruang, Kanokporn Srisucharitpanit, Monrudee Srisaisup, Albert J. Ketterman and Panadda Boonserm

    Citation: BMC Structural Biology 2015 15:17

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  12. Content type: Research article

    Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface. Upstream of the catalytic domain of NanA is a domain that conforms to the s...

    Authors: Lei Yang, Helen Connaris, Jane A. Potter and Garry L. Taylor

    Citation: BMC Structural Biology 2015 15:15

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    The Erratum to this article has been published in BMC Structural Biology 2015 15:19

  13. Content type: Research article

    Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moie...

    Authors: Oleg V. Tsodikov, Caixia Hou, Christopher T. Walsh and Sylvie Garneau-Tsodikova

    Citation: BMC Structural Biology 2015 15:13

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  14. Content type: Research article

    Stationary phase survival proteins (Sps) were found in Firmicutes as having analogous domain compositions, and in some cases genome context, as the resuscitation promoting factors of Actinobacteria, but with a...

    Authors: Doris H.X. Quay, Ambrose R. Cole, Adam Cryar, Konstantinos Thalassinos, Mark A. Williams, Sanjib Bhakta and Nicholas H. Keep

    Citation: BMC Structural Biology 2015 15:12

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  15. Content type: Research article

    Polymyxin B resistance protein D (PmrD) plays a key role in the polymyxin B-resistance pathway, as it is the signaling protein that can act as a specific connecter between PmrA/PmrB and PhoP/PhoQ. We conducted...

    Authors: Hunho Jo, Eui Young Jeong, Jinseong Jeon and Changill Ban

    Citation: BMC Structural Biology 2014 14:24

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  16. Content type: Research article

    Bacterial pyruvate decarboxylases (PDC) are rare. Their role in ethanol production and in bacterially mediated ethanologenic processes has, however, ensured a continued and growing interest. PDCs from Zymomonas m...

    Authors: Leonardo J van Zyl, Wolf-Dieter Schubert, Marla I Tuffin and Don A Cowan

    Citation: BMC Structural Biology 2014 14:21

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  17. Content type: Research article

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the s...

    Authors: Catherine N Leettola, Mary Jane Knight, Duilio Cascio, Sigrid Hoffman and James U Bowie

    Citation: BMC Structural Biology 2014 14:17

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  18. Content type: Research article

    EPR-based distance measurements between spin labels in proteins have become a valuable tool in structural biology. The direct translation of the experimental distances into structural information is however of...

    Authors: Nicole Florin, Olav Schiemann and Gregor Hagelueken

    Citation: BMC Structural Biology 2014 14:16

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  19. Content type: Research article

    The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reacti...

    Authors: Andrew M Ellisdon, Qingwei Zhang, Michelle A Henstridge, Travis K Johnson, Coral G Warr, Ruby HP Law and James C Whisstock

    Citation: BMC Structural Biology 2014 14:14

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